Results 51 to 60 of about 585,812 (289)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Aluminum-alloyed lightweight stainless steels strengthened by B2-(Ni,Fe)Al precipitates

Materials & Design, 2021
The age hardenability of Al-alloyed lightweight stainless steels with the base chemical composition Fe–10.5Cr–3Al (wt.%) and Ni concentrations in the range 3–15 wt.% was studied.
M. Harwarth, G. Chen, R. Rahimi, H. Biermann, A. Zargaran, M. Duffy, M. Zupan, J. Mola   +7 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Superior strength–ductility combination in Al alloys via dislocation gradient structure

Materials Research Letters, 2023
The precipitation hardening is widely applied to strengthen Al alloys. Here, we report an alternative way to achieve high-strength Al alloys via forming the dislocation gradient through pre-torsion.
Feng Wang, Yue Li, Xinren Chen, Huan Zhao, Khurram Yaqoob, Yong Du, Zhangwei Wang, Min Song   +7 more
doaj   +1 more source

Superfunctionalities in Nanodispersive Precipitation-Hardened Alloys

Physical Review Letters, 2012
Although nanodispersive precipitation-hardened alloys have been intensively studied over decades as important structural materials, the possibility that these alloys may have superfunctional properties has been completely overlooked. As shown in this Letter, they may have giant low-hysteretic strain responses to external stimuli if the nanosized single-
Wei-Feng, Rao, Armen G, Khachaturyan
openaire   +3 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Constructing multi-level heterogeneous structures in multi-principal element alloys for superior cryogenic tensile properties

Materials & Design
The multi-level heterogeneous structures, consisting of heterogeneous grain structure, B2 nanoprecipitates, and chemical short-range ordering (CSROs), were designed and fabricated in the (CoNiV)95Al5 multi-principal element alloy.
Luke Xu, Yan Ma, Guohao Qin, Ping Jiang, Xiaolei Wu, Fuping Yuan   +5 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Precipitation hardening of an Al-4.2wt% Mg-0.6wt% Cu alloy

, 1998
The precipitation hardening of an experimental Al-4.2 wt% Mg-0.6 wt% Cu alloy has been studied. After a first initial jump, the yield strength increases almost linearly with the logarithm of the ageing time and a peak of hardness is reached after 11 days
Ratchev, Petar, De Smet, Peter, Verlinden, Bert, Van Houtte, Paul   +3 more
core   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source