Results 51 to 60 of about 12,952 (301)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Maximizing precipitation hardening effect enables ultrahigh strength in a coarse-grained Mg-13Gd forging alloy

Journal of Magnesium and Alloys
In this work, a new strategy for achieving ultrahigh strength in the coarse-grained Mg-Gd binary alloy via utilizing recrystallization texture hardening and maximizing precipitation strengthening has been reported.
Dongdong Zhang, Hucheng Pan, Zhihao Zeng, Weineng Tang, Jingren Li, Hongbo Xie, Rongguang Li, Yuping Ren, Gaowu Qin   +8 more
doaj   +1 more source

The effect of steam treatment and precipitation hardening on the mechanical properties and wear resistance of sintered iron and iron-copper alloys [PDF]

, 1980
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Steam treatments reduce porosity(1) of sintered iron and sintered iron-base alloy products and provide them with increased compressive strength, hardness,
Razavizadeh, K, Razavizadeh, Kamaladin
core  

Precipitation hardening of high entropy alloy CoCrFeMnNi containing titanium [PDF]

, 2022
Art. 157610The effect of titanium addition beyond the solubility limit was investigated in order to proof the precipitation hardening possibility of the Cantor alloy CoCrFeMnNi.
Eißmann, N., Gaitzsch, U., Kieback, B., Mühle, U., Walther, G., Weißgärber, T.   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Influence of Extrusion Temperature on the Aging Behavior and Mechanical Properties of an AA6060 Aluminum Alloy

Metals, 2018
Processing of AA6060 aluminum alloys for semi-products usually includes hot extrusion with subsequent artificial aging for several hours. Processing below the recrystallization temperature allows for an increased strength at a significantly reduced ...
Nadja Berndt, Philipp Frint, Martin F.-X. Wagner   +2 more
doaj   +1 more source

Effect of thixoforming and precipitation hardening on microstructure and mechanical properties of Al-10.5Si–3Cu-0.2Mg alloy produced by strain induced melt activation process

Journal of Materials Research and Technology, 2021
The effects of the thixoforming and the precipitation hardening heat treatment on the microstructure and mechanical properties of Al-10.5Si–3Cu-0.2Mg alloy produced by the strain-induced melt activation (SIMA) process have been investigated. According to
S.G. Shabestari, M. Abdi, S. Naghdali
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effect of the over-ageing treatment on the mechanical properties of AA2024 aluminum alloy. [PDF]

, 2012
The evolution of the hardness of the over-ageing AA2024 alloy scale was followed by measurements of Vickers hardness. The nanoindentation is adapted to the determination of elastoplastic properties (hardness and Young’s modulus) of the matrix and also of
Alexis, Joël, Vulpe, Sanda, Radutoiu, Nicoleta, Abrudeanu, Marioara, Marioara Abrudeanu, Petit, Jacques-Alain, Lacroix, Loïc, Rizea, Vasile, Vasile Rizea, Nicoleta Radutoiu, Jacques-Alain Petit, Joël Alexis, Loic Lacroix, Sanda Vulpe   +13 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source