Results 141 to 150 of about 101,629 (318)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Exploring Signals on L5/E5a/B2a for Dual-Frequency GNSS Precise Point Positioning. [PDF]

Sensors (Basel), 2021
Naciri N, Hauschild A, Bisnath S.
europepmc   +1 more source

Biasschätzung für Precise Point Positioning

, 2017
Precise point positioning with un-differenced observations requires the precise knowledge of satellite biases. In this thesis, new algorithms for the estimation of satellite code and phase biases with a network of reference receivers are proposed.
Wen, Zhibo
core  

Method of Development of a New Regional Ionosphere Model (RIM) to Improve Static Single-Frequency Precise Point Positioning (SF-PPP) for Egypt Using Bernese GNSS Software [PDF]

, 2023
Ashraf Abdallah, Tarek Agag, Volker Schwieger   +2 more
openalex   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Ensuring globally the TanDEM-X height accuracy: Analysis of the reference data sets ICESat, SRTM and KGPS-tracks

, 2009
The TanDEM-X mission will derive a global digital elevation model (DEM) with satellite SAR interferometry. Height references play an important role to ensure the required height accuracy of 10m absolute and 2m relative for 90% of the data.
Roth, Achim, M. Huber, Felbier, Andreas, Huber, Martin, A. Felbier, A. Wendleder, Habermeyer, Martin, Wendleder, Anna, B. Wessel, D. Kosmann, M. Habermeyer, V. Schwieger, A. Roth, Wessel, Birgit, Kosmann, Detlev, Schwieger, Volker   +15 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Precise Point Positioning with raPPPid

Precise Point Positioning (PPP) is an effective GNSS positioning method for various high-precision applications. PPP utilizes precise satellite products, accurate error modeling, and advanced algorithms to achieve centimeter or even millimeter level ...
Wareyka-Glaner, Marcus Franz; orcid:
core