Results 101 to 110 of about 2,616,182 (244)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Computer Viewing Model for Classification of Erythrocytes Infected with Plasmodium spp. Applied to Malaria Diagnosis Using Optical Microscope

Medicina
Background and Objectives: Malaria is a disease that can result in a variety of complications. Diagnosis is carried out by an optical microscope and depends on operator experience.
Eduardo Rojas, Irene Cartas-Espinel, Priscila Álvarez, Matías Moris, Manuel Salazar, Rodrigo Boguen, Pablo Letelier, Lucia San Martín, Valeria San Martín, Camilo Morales, Neftalí Guzmán   +10 more
doaj   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Algunos aspectos que pueden influir en el rigor y veracidad del muestreo de pastos y forrajes

AIA Avances en Investigación Agropecuaria, 2014
Para lograr la representatividad de la población de pasto, es preciso conocer los factores que pueden influir en el muestreo. El presente artículo tiene como objetivo informar los resultados obtenidos en Cuba, relacionados con la toma y procesamiento de ...
Rafael S. Herrera García
doaj  

Antropología implacable

Revista Argentina de Antropología Biológica
La antropología, durante su institucionalización en el siglo XIX, adoptó y desarrolló un variado corpus instrumental a fin de reemplazar las descripciones de las variantes físicas humanas por números.
Marina L. Sardi, Mara Dettler, Lucía V. Arcidiácono   +2 more
doaj   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

A new initiative on precision medicine.

New England Journal of Medicine, 2015
Francis S. Collins, Harold Varmus
semanticscholar   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Intervalos de referencia de parámetros hematológicos en población chilena adulta y en la etnia mapuche

Advances in Laboratory Medicine
Los intervalos de referencia (IR) son una herramienta esencial para apoyar la toma de decisiones clínicas. Estos pueden presentar variaciones intra e interindividuales asociadas a diferencias genéticas y factores medioambientales.
Letelier Pablo J., Chicahual Carolina A., Arroyo Nicolás F., Monsalves Daniel P., Boguen Rodrigo E., Guzmán Neftalí H.   +5 more
doaj   +1 more source