Results 151 to 160 of about 1,922,046 (318)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

REAL OPTIONS ANALYSIS FOR INVESTMENT IN ORGANIC WHEAT AND BARLEY PRODUCTION IN SOUTH CENTRAL NORTH DAKOTA USING PRECISION AGRICULTURE TECHNOLOGY

Real options theory is employed to measure the value of investing in organic wheat production using precision agriculture technology. Results reveal that an option to wait until market uncertainty is resolved is valuable.
Golub, Alla A., Ehmke, Mariah D., Harbor, Anetra L., Boehlje, Michael   +3 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Factors Influencing Cotton Farmers’ Perceptions about the Importance of Information Sources in Precision Farming Decisions

Information generated by precision farming technologies is of particular importance to producers. Precision farming technologies implies the ability to improve the management of production factors using site-specific information.
Roberts, Roland K., English, Burton C., Larson, James A., Lambert, Dayton M., Velandia, Margarita M., Mendieta, Maria P., Rejesus, Roderick M., Mishra, Ashok K.   +7 more
core  

Fontes de erros na mensuração do comprimento e peso de larvas de peixes = Origins of sampling errors in length and weight measurements of fish larvae

Acta Scientiarum: Biological Sciences, 2008
Trabalhos com larvas de peixes, sejam de cultivo ou ecológicos, invariavelmente empregam o comprimento e o peso como parâmetros. Assim sendo, este experimento foi realizado com larvas de Lophiosilurus alexandri, pacamã, objetivando determinar algumas ...
Marcelo Mattos Pedreira, José Cláudio Epaminondas dos Santos, Edson Vieira Sampaio, Janaina de Lima Silva, Felipe Nilvan Ferreira   +4 more
doaj  

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

A Whole- Farm Investment Analysis of Some Precision Agriculture Technologies

This study uses a farm in the Victorian Mallee over the period 1998 2005 to analyse whole-farm profitability and risks of investing in Precision Agriculture and Site-Specific Crop Management systems.
Malcolm, Bill, Knight, Brad
core  

A single site, multi-operator precision study for second-generation HR-pQCT. [PDF]

JBMR Plus
Stapleton JR, Heilmann NZ, Cattell K, Burghardt AJ, Beavers DP, Madrid DA, Brandt KM, Delanie Lynch S, Weaver AA.   +8 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source