Results 181 to 190 of about 1,922,046 (318)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Precision Teaching: Fast Practice or Merely More Practice Results in Better Learning?

open access: yes, 2009
Doughty, Chase and O'Shields (2004) reviewed the Precision Teaching literature which they point out claimed that Precision Teaching is superior in producing learning outcomes and they posed concerns about the lack of well designed research to support ...
Kong, Xiuyan
core  

In Vivo Complete Arch Implant Impressions: Comparison of the Linear Precision of Digital and Conventional Techniques. [PDF]

open access: yesInt Dent J
Martínez-Marugán A   +5 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Assessing Investment in Precision Farming for Reducing Pesticide Use in French Viticulture

open access: yes
The paper develops a mathematical programming model for assessing the impact of Environmental Policy instruments on French winegrowing farm’s adoption of pesticides-saving technologies. We model choices with regards to investment in precision farming and
Souville, Genevieve   +2 more
core  

STELLAR-CB: Synthetic Temporal LSTM for Livestock Activity Recognition-Cow Behaviour. [PDF]

open access: yesVet Med Sci
Ahmed G   +9 more
europepmc   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

open access: yesFEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura   +19 more
wiley   +1 more source

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