Results 21 to 30 of about 365,969 (214)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Comparison of Single-Arm and Dual-Arm Collaborative Robots in Precision Assembly
Applied SciencesThe aim of the study is a multi-criteria comparative evaluation of robots cooperating with humans in single- and dual-arm variants used for the process of precise assembly of complex parts.
Katarzyna Peta +3 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Design, Analysis, and Implementation of a 3-DOF Spherical Parallel Manipulator
IEEE AccessThe agile eye is classified as a 3-degrees of freedom (DOF) type 3-RRR spherical parallel mechanism (SPM) designed to replicate the movement patterns seen in the human eye.
Mohamed Djennane +5 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Integrated cancer tissue engineering models for precision medicine.
PLoS ONE, 2019 Tumors are not merely cancerous cells that undergo mindless proliferation. Rather, they are highly organized and interconnected organ systems. Tumor cells reside in complex microenvironments in which they are subjected to a variety of physical and ...
Michael E Bregenzer +6 more
doaj +1 more source
Improved Cell-Penetrating Zinc-Finger Nuclease Proteins for Precision Genome Engineering
Molecular Therapy: Nucleic Acids, 2015 Safe, efficient, and broadly applicable methods for delivering site-specific nucleases into cells are needed in order for targeted genome editing to reach its full potential for basic research and medicine.
Jia Liu +3 more
doaj +1 more source
Towards metropolitan free-space quantum networks
npj Quantum Information, 2023 Quantum communication has seen rapid progress towards practical large-scale networks, with quantum key distribution (QKD) spearheading this development.
Andrej Kržič +20 more
doaj +1 more source