Results 51 to 60 of about 365,969 (214)

Precision game engineering through reshaping strategic payoffs

Scientific Reports
Nash equilibrium is a key concept in game theory fundamental for elucidating the equilibrium state of strategic interactions, with applications in diverse fields such as economics, political science, and biology.
Elie Eshoa, Ali R. Zomorrodi
doaj   +1 more source

Smart Vesicle Therapeutics: Engineering Precision at the Nanoscale

Pharmaceutics
Smart vesicle therapeutics represent a transformative frontier in nanomedicine, offering precise, biocompatible, and adaptable platforms for drug delivery and theranostic applications. This review explores recent advances in the design and engineering of
Luciano A. Benedini, Paula V. Messina
doaj   +1 more source

Investigation of Error Sources Measuring Deformations of Engineering Structures by Geodetic Methods

The Baltic Journal of Road and Bridge Engineering, 2010
Modern bridges and road structures are characterized by large-size objects, the complexity of engineering structures and a high precision of joints and knots of structural elements.
Vladislovas Česlovas Aksamitauskas, Donatas Rekus, Stasys Čirba   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Aptamer guided nanomedicines enable precision immune engineering

Discover Applied Sciences
Precision targeting of immune responses is crucial for the ongoing development of therapies for cancer, autoimmune, and infectious diseases. Aptamers, which are short, single-stranded oligonucleotides, are emerging as powerful immunomodulators in ...
Nowar Alsarayreh, Yousef Ijjeh, Hadeel AbuSaifan, Baida’a AlQuaissi, Nirmeen Elzogheir, Dana Alqudah, Sara Al-Mahamid, Somaya Ahmad, Hamdi Nsairat, Alaaldin M. Alkilany, Alqassem Abuarqoub, Mohammad IA Ahmad, Walhan Alshaer   +12 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Compensation Techniques for Photosensors Used in High-Precision Accelerometers

Micromachines
Temperature exerts a profound influence on the fidelity of photosensors, making the attainment of reliable temperature compensation a formidable task within engineering realms.
Yuan Wei, Jianhua Yang, Pengfei Li, Junling Zhang, Pu Liang   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Engineering support of production of high-precision component assemblies

MATEC Web of Conferences, 2017
In the present paper the discipline of the holistic approach (complex of design procedures) which provide the effectiveness of the realization of the assembly operations is considered.
Nazaryev Alexandr, Bochkarev Petr
doaj   +1 more source