Results 51 to 60 of about 179,712 (259)

Neuromorphic-enabled video-activated cell sorting

Nature Communications
Imaging flow cytometry allows image-activated cell sorting (IACS) with enhanced feature dimensions in cellular morphology, structure, and composition.
Weihua He, Junwen Zhu, Yongxiang Feng, Fei Liang, Kaichao You, Huichao Chai, Zhipeng Sui, Haiqing Hao, Guoqi Li, Jingjing Zhao, Lei Deng, Rong Zhao, Wenhui Wang   +12 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Polarization-independent total-internal-reflection grism with 95% diffraction efficiency for wavelength selective switches [PDF]

EPJ Web of Conferences
A polarization-independent reflective grism consists of a polarization-independent total-internal-reflection grating and a prism. It can offer high line density, wide bandwidth and linear dispersion, promising potential application to next-generation ...
Shen Sitong, Zeng Lijiang, Li Lifeng
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Highly Controllable Fabrication of Gold Composite Nanostructures by Multiple Electroplating for High‐Performance Electrochemical and Raman Scattering Measurements

Small Structures
Morphology‐controlled nanostructures are important functional materials in multidisciplinary research fields, such as sensing, imaging, catalysis, and energy harvesting.
Shengsen Zhang, Shengjie Chen, Kunru Yu, Rong Zhu   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Robust Space-Object Association and Recursive Estimation for Ground-Based Optical Observation Under Degraded Orbital Priors and Site-Position Uncertainty

Remote Sensing
Ground-based optical observation is a key sensing modality for space-object monitoring, but reliable association becomes challenging when orbital priors are degraded, site-position information is imprecise, and each frame contains multiple point-source ...
Tingkai Yan, Xinyuan Liu, Shuaipeng Hou, Jianing Yang, Hongtong Li, Fei Xing   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Multi-Sensor Registration in High-Precision CMM Based on a Composite Standard

Sensors, 2018
Registration is a critical step in multi-sensor dimensional measurement. As the accuracy of registration directly impacts the quality of final results, a reference sphere as a common standard is problematic in high-precision registration.
Yan Zhao, Yiwen Wang, Xiuling Ye, Zhong Wang, Luhua Fu, Changjie Liu, Zhiwei Wang   +6 more
doaj   +1 more source