Results 61 to 70 of about 179,228 (306)

Photonic diffractive generators through sampling noises from scattering media

Nature Communications
Photonic computing, with potentials of high parallelism, low latency and high energy efficiency, have gained progressive interest at the forefront of neural network (NN) accelerators.
Ziyu Zhan, Hao Wang, Qiang Liu, Xing Fu
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Neuromorphic-enabled video-activated cell sorting

Nature Communications
Imaging flow cytometry allows image-activated cell sorting (IACS) with enhanced feature dimensions in cellular morphology, structure, and composition.
Weihua He, Junwen Zhu, Yongxiang Feng, Fei Liang, Kaichao You, Huichao Chai, Zhipeng Sui, Haiqing Hao, Guoqi Li, Jingjing Zhao, Lei Deng, Rong Zhao, Wenhui Wang   +12 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The high precision double slit device of the slit assembly for the FLEX instrument [PDF]

, 2021
Matthias Mohaupt, Uwe D. Zeitner, Gerd Harnisch, Thomas Bolz, Stefan Risse, Andreas Gebhardt, Henrik von Lukowicz, Thomas Peschel, Uwe Hübner, Yann Gerome, Markus Erhard, Gehard Huber   +11 more
openalex   +1 more source

Automated multiphysics MEMS co-optimization platform: Integrated fabrication constraints and accelerated design for high-linearity sensors [PDF]

Nanotechnology and Precision Engineering
This paper proposes an innovative automated multiphysics Microelectromechanical systems (MEMS) co-optimization platform integrating the embedded reduced-order modeling offered by Coventor MEMS+ with MATLAB’s numerical computing environment, addressing ...
Peizhi Yu, Chenzi Wang, Wenshuai Lu, Zheng You   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Multi-Sensor Registration in High-Precision CMM Based on a Composite Standard

Sensors, 2018
Registration is a critical step in multi-sensor dimensional measurement. As the accuracy of registration directly impacts the quality of final results, a reference sphere as a common standard is problematic in high-precision registration.
Yan Zhao, Yiwen Wang, Xiuling Ye, Zhong Wang, Luhua Fu, Changjie Liu, Zhiwei Wang   +6 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source