Results 141 to 150 of about 507,954 (312)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Precision measurement of cardiac structure and function in cardiovascular magnetic resonance using machine learning. [PDF]

J Cardiovasc Magn Reson, 2022
Davies RH, Augusto JB, Bhuva A, Xue H, Treibel TA, Ye Y, Hughes RK, Bai W, Lau C, Shiwani H, Fontana M, Kozor R, Herrey A, Lopes LR, Maestrini V, Rosmini S, Petersen SE, Kellman P, Rueckert D, Greenwood JP, Captur G, Manisty C, Schelbert E, Moon JC.   +23 more
europepmc   +1 more source

Orthogonal distance fitting of precision free form surfaces based on l1 norm

, 2008
Precision free-form surfaces are widely used in advanced optical and mechanical devices. In order to evaluate the form quality of a free-form surface, it is required to fit the measurement data with the design template and compare the relative deviation ...
Zhang, Xiangchao, Jiang, Xiang, Scott, Paul J.   +2 more
core  

Error sources, measurement uncertainties and calibration techniques in high-precision metrology

, 2022
S.427-430Although high-precision measuring devices, e.g. interferometers, are emerging more and more from the laboratory into the shop floor, many users are totally oblivious to potential errors that inevitably creep into the measuring process.
Pfeifer, Tilo, Mischo, Horst, Bitte, Frank   +2 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Every gene everywhere all at once: High-precision measurement of 3D chromosome architecture with single-cell Hi-C. [PDF]

Front Mol Biosci, 2022
Chi Y, Shi J, Xing D, Tan L.
europepmc   +1 more source

Measurement of absolute phase error of digitizers

, 2018
Some engineering applications, such as Phasor Measurement Unit and calibration of instrument transformers with digital output, require the knowledge of phase error of digitizers, to reach high phase measurement accuracy.
D. Gallo, M. Luiso, G. Crotti, Femine, A. Delle, Luiso, M., A. Delle Femine, Landi, C., C. Landi, Crotti, G., D. Giordano, Gallo, D., Giordano, D., Delle Femine, A.   +12 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

K-Schedules Meet Precision Measurement: A Protocol for Intervention. [PDF]

Behav Anal Pract, 2021
Milyko K.
europepmc   +1 more source