Results 191 to 200 of about 4,218,282 (383)
Building SuperModels: emerging patient avatars for use in precision and systems medicine [PDF]
, 2015 Sherry‐Ann Brown
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Experimental pharmacology in precision medicine
Pharmacology Research & Perspectives, 2023 Alicja Urbaniak +8 more
doaj +1 more source
Contribution of Precision Engineering to Regenerative Medicine
, 2014 Toyoshige Kobayashi, Shizu Takeda
openalex +2 more sources
Introduction to the Theme “Precision Medicine and Prediction in Pharmacology” [PDF]
, 2015 Paul A. Insel +2 more
openalex +1 more source
Radiomics and Artificial Intelligence for Precision Medicine in Lung Cancer Treatment.
Seminars in Cancer Biology, 2023 Mitchell Chen +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Precision medicine in the clouds [PDF]
Nature Biotechnology, 2018 Vogt, Henrik +2 more
openaire +3 more sources
“Cancer 2015”: A Prospective, Population-Based Cancer Cohort—Phase 1: Feasibility of Genomics-Guided Precision Medicine in the Clinic [PDF]
, 2015 John P. Parisot +17 more
openalex +1 more source