Results 231 to 240 of about 789,487 (311)

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Biomaterials and Tissue Engineering Strategies for Mastoid Obliteration: A Systematic Review of the Clinical and Preclinical Evidence. [PDF]

J Clin Med
Freda G, Laria C, Mallardo A, Auletta G, Murri A, Pontillo V, Danti S, Serra N, De Vito A, Quaranta NAA, Berrettini S, Fetoni AR.   +11 more
europepmc   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Procedural Errors Associated With the Use of Rotary and Reciprocating Endodontic Instruments in Undergraduate Settings: A Scoping Review. [PDF]

Int J Dent
Hassouneh L, Shamiyah DA.
europepmc   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Data Analysis Planning and Reporting for Confirmatory Multi-Lab Preclinical Trials: A Tutorial. [PDF]

Biom J
Arroyo-Araujo M, Carneiro CFD, Piper SK, Wilcke JC, Ellenbach N, Boulesteix AL, Emprechtinger R, Ineichen BV, Riecken LB, Haller B, Voelkl B, Held L, Konietschke F, Toelch U.   +13 more
europepmc   +1 more source

Toward targeted therapeutics for lobular breast cancer. [PDF]

J Clin Invest
Fanucci KA, Bahnassy S, Roy AM, Sokolova A, Stover DG, Simpson PT, Riggins RB, Jeselsohn R.   +7 more
europepmc   +1 more source

New Obesity Definition and Clinical Obesity Prevalence for Global Metabolic Bariatric Surgery.

JAMA Netw Open
Cremona S, Cohen RV, Pattou F, Casajoana A, Sampaio Souza G, Raverdy V, Verkindt H, Blasio BTL, Roser P, Caiazzo R, Benaiges D, Zanata Petry TB, Rubino F.   +12 more
europepmc   +1 more source