Results 61 to 70 of about 714,050 (315)

Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents

eLife
C-C chemokine receptor type 5 (CCR5) antagonists may improve both acute stroke outcome and long-term recovery. Despite their evaluation in ongoing clinical trials, gaps remain in the evidence supporting their use.
Ayni Sharif, Matthew S Jeffers, Dean A Fergusson, Raj Bapuji, Stuart G Nicholls, John Humphrey, Warren Johnston, Ed Mitchell, Mary-Ann Speirs, Laura Stronghill, Michele Vuckovic, Susan Wulf, Risa Shorr, Dar Dowlatshahi, Dale Corbett, Manoj M Lalu   +15 more
doaj   +1 more source

Bisphosphonates: Preclinical Review

The Oncologist, 2004
Abstract Learning Objectives After completing this course, the reader will be able to: Describe the mechanism of action of first-generation and nitrogen-containing bisphosphonates. Explain how the mechanism of action of the bisphosphonates might directly affect tumor growth.
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Eight practical strategies for designing case-based flipped learning to foster clinical reasoning in preclinical medical students

Annals of Medicine
Background Flipped learning has gained increasing attention in health professions education, demonstrating potential advantages over traditional teaching methods.
Jihyun Si
doaj   +1 more source

Status Go for Preclinical Imaging

, 2020
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject.

core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Comparison of Mono-Layer and Two-Layers Phantom Teeth Used in Preclinical Courses

, 2014
Introduction and aim of study: Preclinical practical exercises are an important part of teaching dentistry. It takes place on the phantom simulators, jaws and teeth in the adapted phantom labs.
K. Foukalová, K. Francová, I. Voborná
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Metformin Synergistically Enhanced the Antitumor Activity of Celecoxib in Human Non-Small Cell Lung Cancer Cells

Frontiers in Pharmacology, 2020
Celecoxib has potential as an effective antineoplastic agent, but it may exhibit side effects. Given the glucose-addicted properties of tumor cells, metformin is recognized for its inhibitory effect on oxidative phosphorylation.
Nini Cao, Yanyan Lu, Jia Liu, Fangfang Cai, Huangru Xu, Jia Chen, Xiangyu Zhang, Zi-Chun Hua, Zi-Chun Hua, Hongqin Zhuang   +9 more
doaj   +1 more source

In Vivo Metabolism in Preclinical Drug Development

, 2008
[No abstract ...

core   +1 more source