Results 41 to 50 of about 789,487 (311)

Cognitive indicators of transition to preclinical and prodromal stages of Alzheimer's disease in Down syndrome

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction There is a critical need to identify measures of cognitive functioning sensitive to early Alzheimer's disease (AD) pathophysiology in Down syndrome to advance clinical trial research in this at‐risk population. The objective of the study was
Sigan L. Hartley, Benjamin L. Handen, Darlynne Devenny, Dana Tudorascu, Brianna Piro‐Gambetti, Matthew D. Zammit, Charles M. Laymon, William E. Klunk, Shahid Zaman, Annie Cohen, Bradley T. Christian   +10 more
doaj   +1 more source

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self‐ and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively ...
Gonzalo Sánchez‐Benavides, Gemma Salvadó, Eider M. Arenaza‐Urquijo, Oriol Grau‐Rivera, Marc Suárez‐Calvet, Marta Milà‐Alomà, José María González‐de‐Echávarri, Carolina Minguillon, Marta Crous‐Bou, Aida Niñerola‐Baizán, Andrés Perissinotti, Juan Domingo Gispert, José Luis Molinuevo, for the ALFA Study   +13 more
doaj   +1 more source

Preclinical pharmacokinetics of benznidazole [PDF]

British Journal of Cancer, 1984
Benznidazole is a lipophilic analogue of misonidazole (MISO) which shows promise as a chemosensitizer for clinical use, particularly in combination with CCNU. We have investigated the detailed pharmacokinetics of benznidazole in mice, dogs and sheep to provide a data base for the estimation of doses required for chemosensitization in man ...
P, Workman, R A, White, M I, Walton, L N, Owen, P R, Twentyman   +4 more
openaire   +2 more sources

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

An economic evaluation of preclinical testing strategies compared to the compulsory scrapie flock scheme in the control of classical scrapie [PDF]

, 2012
Cost-benefit is rarely combined with nonlinear dynamic models when evaluating control options for infectious diseases. The current strategy for scrapie in Great Britain requires that all genetically susceptible livestock in affected flocks be culled ...
Fiona Houston, Kao, R., Boden, L., Kao, Rowland, Fryer Helen, Hawkins, Neil, Helen Fryer, Handel, I., Boden Lisa, Hawkins, N., Handel Ian, Ian Handel, Fryer, Helen, Houston Fiona, Kao Rowland, Handel, Ian, Hawkins Neil, Rowland Kao, Fryer, H., Boden, Lisa, Houston, Fiona, Lisa Boden, Houston, F., Neil Hawkins   +23 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Assessing the Completeness of Reporting in Preclinical Oncolytic Virus Therapy Studies [PDF]

, 2019
Irreproducibility of preclinical findings could be a significant barrier to the “bench-to-bedside” development of oncolytic viruses (OVs). A contributing factor is the incomplete and non-transparent reporting of study methodology and design.
Conic, Isidora, Leung, Garvin J, Lalu, Manoj M, Ilkow, Carolina, Wesch, Neil L, Presseau, Justin, Kimmelman, Jonathan, Cobey, Kelly D, Auer, Rebecca, Diallo, Jean-Simon, MacNeil, Jenna L, Krishnan, Ramya, Kekre, Natasha, El-Sayes, Nader, Keller, Brian A, Fergusson, Dean A   +15 more
core   +1 more source

Standardisation of preclinical PET/CT protocols across multiple research centres [PDF]

, 2020
Preclinical Positron Emission Tomography/Computed Tomography (PET/CT) is a well-established non-invasive imaging tool for studying disease development/progression, the development of novel radiotracers and pharmaceuticals for clinical applications ...
McDougald, Wendy Anne
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source