Results 41 to 50 of about 714,050 (315)

Cognitive indicators of transition to preclinical and prodromal stages of Alzheimer's disease in Down syndrome

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction There is a critical need to identify measures of cognitive functioning sensitive to early Alzheimer's disease (AD) pathophysiology in Down syndrome to advance clinical trial research in this at‐risk population. The objective of the study was
Sigan L. Hartley, Benjamin L. Handen, Darlynne Devenny, Dana Tudorascu, Brianna Piro‐Gambetti, Matthew D. Zammit, Charles M. Laymon, William E. Klunk, Shahid Zaman, Annie Cohen, Bradley T. Christian   +10 more
doaj   +1 more source

Assessing the Completeness of Reporting in Preclinical Oncolytic Virus Therapy Studies [PDF]

, 2019
Irreproducibility of preclinical findings could be a significant barrier to the “bench-to-bedside” development of oncolytic viruses (OVs). A contributing factor is the incomplete and non-transparent reporting of study methodology and design.
Conic, Isidora, Leung, Garvin J, Lalu, Manoj M, Ilkow, Carolina, Wesch, Neil L, Presseau, Justin, Kimmelman, Jonathan, Cobey, Kelly D, Auer, Rebecca, Diallo, Jean-Simon, MacNeil, Jenna L, Krishnan, Ramya, Kekre, Natasha, El-Sayes, Nader, Keller, Brian A, Fergusson, Dean A   +15 more
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self‐ and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively ...
Gonzalo Sánchez‐Benavides, Gemma Salvadó, Eider M. Arenaza‐Urquijo, Oriol Grau‐Rivera, Marc Suárez‐Calvet, Marta Milà‐Alomà, José María González‐de‐Echávarri, Carolina Minguillon, Marta Crous‐Bou, Aida Niñerola‐Baizán, Andrés Perissinotti, Juan Domingo Gispert, José Luis Molinuevo, for the ALFA Study   +13 more
doaj   +1 more source

Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse

, 2012
Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Ulrich Dirnagl, Members of the MCAO-SOP Group   +1 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Proposed phases for implementing rigorous preclinical experimental study design and transparent reporting for preclinical researchers.

, 2023
Proposed phases for implementing rigorous preclinical experimental study design and transparent reporting for preclinical researchers.
Victoria T. Hunniford (10751750), Carolina Ilkow (5424632), Matthew S. Jeffers (10536845), Manoj M. Lalu (7775576), Dean A. Fergusson (7775588), Jamie C. Brehaut (9978644), Ayni Sharif (14334411), Kelly D. Cobey (8736732), Analyssa Cardenas (13027548), Joshua Montroy (848622), Madison K. Foster (14334408), Justin Presseau (39423)   +11 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Preclinical Assessment of Ketamine [PDF]

CNS Neuroscience & Therapeutics, 2013
SummaryKetamine is used as a general anesthetic, and recent data suggest that anesthetics can cause neurodegeneration and/or neuroprotection. The precise mechanisms are not completely understood. This review is to examine the work on ketamine and to address how developmental biology may be utilized when combined with biochemical, pathological, and ...
Cheng, Wang, Fang, Liu, Tucker A, Patterson, Merle G, Paule, William, Slikker   +4 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source