Results 31 to 40 of about 714,050 (315)

Targeting Sphingolipids for Cancer Therapy

Frontiers in Oncology, 2021
Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from proliferation to cell death. Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis ...
Osmel Companioni, Cristina Mir, Yoelsis Garcia-Mayea, Matilde E. LLeonart, Matilde E. LLeonart   +4 more
doaj   +1 more source

3rd TPCF Preclinical Symposium Imaging(TPIS 2020)

Frontiers in Biomedical Technologies, 2020
The path of discovering/designing a molecule to developing a novel drug could take up to an average of 12 years and costs around $1 billion (USD). Preclinical phase is a major step on this path and is the part where scientists perform additional studies ...
3rd TPCF Preclinical Symposium Imaging (TPIS 2020)
doaj  

Radiotherapy and erlotinib combined: review of the preclinical and clinical evidence

Frontiers in Oncology, 2012
Epidermal growth factor receptor is often overexpressed in tumors and has been associated with poor prognosis in some cancer types. The introduction of inhibitors of epidermal growth factor receptor, such as erlotinib and cetuximab, represents an ...
Vivek Krishan Mehta
doaj   +1 more source

From Bedside to the Bench—A Call for Novel Approaches to Prognostic Evaluation and Treatment of Empyema

Frontiers in Pharmacology, 2022
Empyema, a severe complication of pneumonia, trauma, and surgery is characterized by fibrinopurulent effusions and loculations that can result in lung restriction and resistance to drainage.
Sophia Karandashova, Galina Florova, Steven Idell, Andrey A. Komissarov   +3 more
doaj   +1 more source

MR histology reveals tissue features beneath heterogeneous MRI signal in genetically engineered mouse models of sarcoma

Frontiers in Oncology
PurposeTo identify significant relationships between quantitative cytometric tissue features and quantitative MR (qMRI) intratumorally in preclinical undifferentiated pleomorphic sarcomas (UPS).Materials and methodsIn a prospective study of genetically ...
Stephanie J. Blocker, Yvonne M. Mowery, Jeffrey I. Everitt, James Cook, Gary Price Cofer, Yi Qi, Alex M. Bassil, Eric S. Xu, David G. Kirsch, Cristian T. Badea, G. Allan Johnson   +10 more
doaj   +1 more source

Interregional compensatory mechanisms of motor functioning in progressing preclinical neurodegeneration.

, 2013
Understanding brain reserve in preclinical stages of neurodegenerative disorders allows determination of which brain regions contribute to normal functioning despite accelerated neuronal loss.
Scheller, Elisa, Peter, J, Peter, Jessica, Scheller, E., Peter, J., Abdulkadir, Ahmed, Frackowiak, Richard S. J., Frackowiak, R.S., Klöppel, Stefan, Tabrizi, S.J., Frackowiak, Richard S.J., Abdulkadir, A, Tabrizi, SJ, Frackowiak, RS, Scheller, E, Klöppel, S., Tabrizi, Sarah J., Abdulkadir, A., Klöppel, S   +18 more
core   +1 more source

Standardisation of preclinical PET/CT protocols across multiple research centres [PDF]

, 2020
Preclinical Positron Emission Tomography/Computed Tomography (PET/CT) is a well-established non-invasive imaging tool for studying disease development/progression, the development of novel radiotracers and pharmaceuticals for clinical applications ...
McDougald, Wendy Anne
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse

, 2009
Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Ulrich Dirnagl, Members of the MCAO-SOP Group   +1 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source