Results 21 to 30 of about 714,050 (315)

Preclinical Intracranial Aneurysm Models: A Systematic Review [PDF]

, 2020
Intracranial aneurysms (IA) are characterized by weakened cerebral vessel walls that may lead to rupture and subarachnoid hemorrhage. The mechanisms behind their formation and progression are yet unclear and warrant preclinical studies.
Serge Marbacher, Strange, Fabio, Javier Fandino, Marbacher, Serge, Fabio Strange, Fandino, Javier, Basil E Grüter, Gruter, Basil E   +7 more
core   +1 more source

Losing Control in Controlled Settings: Preclinical Human Research on Impulsivity Within the Context of Addiction

, 2023
Purpose of Review: Impulsivity has long been recognized as a risk factor for addiction. The mechanisms through which impulsivity increases risk remain unclear, hindering development of effective impulsivity-targeted addiction treatments.
Natalie J. Loxton, Renata Almeida Mendes, Gullo, Matthew J, Matthew J. Gullo, Lindsay, Hannah J, Hannah J. Lindsay, Mendes, Renata Almeida, Loxton, Natalie J   +7 more
core   +1 more source

Preclinical characterization and phase I clinical trial of CT053PTSA targets MET, AXL, and VEGFR2 in patients with advanced solid tumors

Frontiers in Immunology, 2022
BackgroundCT053PTSA is a novel tyrosine kinase inhibitor that targets MET, AXL, VEGFR2, FLT3 and MERTK. Here, we present preclinical data about CT053PTSA, and we conducted the first-in-human (FIH) study to evaluate the use of CT053PTSA in adult patients ...
Yu-Xiang Ma, Fu-Rong Liu, Yang Zhang, Qun Chen, Zhi-Qiang Chen, Qian-Wen Liu, Yan Huang, Yun-Peng Yang, Wen-Feng Fang, Ning Xi, Ning Kang, Yu-Lei Zhuang, Qi Zhang, Ying-Zhi Jiang, Li Zhang, Hong-Yun Zhao   +15 more
doaj   +1 more source

Preclinical and Clinical Research Models of Prostate Cancer: A Brief Overview

Life, 2022
The incidence and mortality from prostate cancer (PCa) are on the rise which poses a major public health concern worldwide. In this narrative review, we have summarized the characteristics of major in vitro and in vivo PCa models including their utility ...
Debasish Basak, Lisney Gregori, Fatema Johora, Subrata Deb   +3 more
doaj   +1 more source

Preclinical characterisation of fingolimod as a potential therapeutic agent for stroke [PDF]

, 2022
Stroke is the leading cause for death and disability worldwide, and the search for novel drug treatments has been affected by repeated clinical trial failures.
Diaz Diaz, Andrea C.
core  

Biological Properties and Health-Promoting Functions of Laminarin: A Comprehensive Review of Preclinical and Clinical Studies

Marine Drugs, 2022
Marine algal species comprise of a large portion of polysaccharides which have shown multifunctional properties and health benefits for treating and preventing human diseases.
Shanmugapriya Karuppusamy, Gaurav Rajauria, Stephen Fitzpatrick, Henry Lyons, Helena McMahon, James Curtin, Brijesh K. Tiwari, Colm O’Donnell   +7 more
doaj   +1 more source

MRI as a Tool to Assess Interstitial Cystitis Associated Bladder and Brain Pathologies

Diagnostics, 2021
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic, often incapacitating condition characterized by pain seeming to originate in the bladder in conjunction with lower urinary tract symptoms of frequency and urgency, and consists of a wide ...
Rheal A. Towner, Nataliya Smith, Debra Saunders, Robert E. Hurst   +3 more
doaj   +1 more source

Preclinical Knowledge Retention by MBBS Students during Their Clinical Years: An Observational Study to Analyze Preparedness towards National Exit Test [PDF]

Indian Journal of Medical Biochemistry
Aim and background: One of the challenges to be faced by MBBS students completing their final year henceforth is to face the national exit test (NeXT) to be eligible to practice and start postgraduate studies. The objectives were to compare the retention
Veena Bhaskar S Gowda, Roopashree Ramakrishna, Roopashree Krishna   +2 more
doaj   +1 more source

Evaluating real-patient learning in medical education – Hungarian validation of the Manchester Clinical Placement Index

Frontiers in Medicine, 2023
IntroductionThe Manchester Clinical Placement Index (MCPI) is an instrument to measure medical undergraduates’ real-patient learning in communities of practice both in hospital and in GP placements.
Szabolcs Fábry, Szabolcs Fábry, Sándor Rózsa, Csenge Hargittay, Petra Kristóf, Ágnes Szélvári, Krisztián Vörös, Péter Torzsa, Endre Németh, Endre Németh, Timothy Dornan, Ajándék Eőry   +11 more
doaj   +1 more source

The employment of vaccinia virus for colorectal cancer treatment: A review of preclinical and clinical studies

Human Vaccines & Immunotherapeutics, 2022
Colorectal cancer (CRC) is one of the leading malignancies that causes death worldwide. Cancer vaccines and oncolytic immunotherapy bring new hope for patients with advanced CRC. The capability of vaccinia virus (VV) in carrying foreign genes as antigens
Qiaoyun Ling, Bichun Zheng, Xudong Chen, Shaoshun Ye, Quan Cheng   +4 more
doaj   +1 more source