Results 21 to 30 of about 789,487 (311)
Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse [PDF]
, 2009 Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Ulrich Dirnagl +1 more
core +1 more source
Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse [PDF]
, 2012 Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Ulrich Dirnagl +1 more
core +1 more source
Preclinical Neuropharmacology of Naratriptan [PDF]
CNS Drug Reviews, 2005 ABSTRACTThe basic CNS neuropharmacology of naratriptan is reviewed here. Naratriptan is a second‐generation triptan antimigraine drug, developed at a time when CNS activity was thought not to be relevant to its therapeutic effect in migraine. It was, however, developed to be a more lipid‐soluble, more readily absorbed and less readily metabolized ...
openaire +2 more sources
Frontiers in Immunology, 2022 BackgroundCT053PTSA is a novel tyrosine kinase inhibitor that targets MET, AXL, VEGFR2, FLT3 and MERTK. Here, we present preclinical data about CT053PTSA, and we conducted the first-in-human (FIH) study to evaluate the use of CT053PTSA in adult patients ...
Yu-Xiang Ma +15 more
doaj +1 more source
Preclinical profile of cabazitaxel
Drug Design, Development and Therapy, 2014 First-generation taxanes have changed the treatment paradigm for a wide variety of cancers, but innate or acquired resistance frequently limits their use. Cabazitaxel is a novel second-generation taxane developed to overcome such resistance. In vitro, cabazitaxel showed similar antiproliferative activity to docetaxel in taxane-sensitive cell lines and ...
Vrignaud,Patricia +5 more
openaire +4 more sources
Preclinical Intracranial Aneurysm Models: A Systematic Review [PDF]
, 2020 Intracranial aneurysms (IA) are characterized by weakened cerebral vessel walls that may lead to rupture and subarachnoid hemorrhage. The mechanisms behind their formation and progression are yet unclear and warrant preclinical studies.
Serge Marbacher +7 more
core +2 more sources
Preclinical and Clinical Research Models of Prostate Cancer: A Brief Overview
Life, 2022 The incidence and mortality from prostate cancer (PCa) are on the rise which poses a major public health concern worldwide. In this narrative review, we have summarized the characteristics of major in vitro and in vivo PCa models including their utility ...
Debasish Basak +3 more
doaj +1 more source
, 2023 Purpose of Review: Impulsivity has long been recognized as a risk factor for addiction. The mechanisms through which impulsivity increases risk remain unclear, hindering development of effective impulsivity-targeted addiction treatments.
Natalie J. Loxton +7 more
core +1 more source
Should Peak Dose Be Used to Prescribe Spatially Fractionated Radiation Therapy?—A Review of Preclinical Studies [PDF]
, 2022 SIMPLE SUMMARY: This review study analyzed preclinical studies available before 2022 on spatially fractionated radiation therapy (SFRT), a promising cancer therapy with a high therapeutic index. We intend to use the results of preclinical studies to shed
Prezado, Yolanda +5 more
core +2 more sources
Marine Drugs, 2022 Marine algal species comprise of a large portion of polysaccharides which have shown multifunctional properties and health benefits for treating and preventing human diseases.
Shanmugapriya Karuppusamy +7 more
doaj +1 more source