Results 191 to 200 of about 1,044,728 (382)

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam, Ali Laith, Aslihan Gunel, Melda Yilmaz, Nazli Basak, Halil Idrisoglu, P. Hande Ozdinler   +6 more
wiley   +1 more source

Supplementary Table S6 from Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers

, 2023
Wei Zhou, Peng Fang, Dongan Yu, Hongyuan Ren, Meng You, Long Yin, Fei Mei, Huikai Zhu, Zhenzhen Wang, Hui Xu, Yuxia Cao, Xiaowei Sun, Xiaohong Xu, Jianjun Bi, Jin Wang, Lanping Ma, Xin Wang, Lin Chen, Yongliang Zhang, Xiaowei Cen, Xi Zhu, Liguang Lou, Datao Liu, Xiaoding Tan, Jinliang Yang, Tao Meng, Jingkang Shen   +26 more
openalex   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Cooperative research and development opportunities with the National Cancer Institute [PDF]

The Office of Technology Development (OTD) of the National Cancer Institute (NCI) is responsible for negotiating Cooperative Research and Development Agreements (CRADAs), whereby the knowledge resulting from NCI investigators' government-sponsored ...
Sybert, Kathleen
core   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Supplementary Table S11 from Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers

, 2023
Wei Zhou, Peng Fang, Dongan Yu, Hongyuan Ren, Meng You, Long Yin, Fei Mei, Huikai Zhu, Zhenzhen Wang, Hui Xu, Yuxia Cao, Xiaowei Sun, Xiaohong Xu, Jianjun Bi, Jin Wang, Lanping Ma, Xin Wang, Lin Chen, Yongliang Zhang, Xiaowei Cen, Xi Zhu, Liguang Lou, Datao Liu, Xiaoding Tan, Jinliang Yang, Tao Meng, Jingkang Shen   +26 more
openalex   +1 more source

Amide‐Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non‐Small Cell Lung Adenocarcinoma

Advanced Biology, EarlyView.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti‐inflammatory properties. However, a translation into clinical evidence is still lacking. The current study demonstrates that LA ‐ even at clinically relevant concentrations – exert a strong anti‐tumoral effect in a complex ex vivo model patient ...
Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta‐Carolin Pietsch, Sebastian N. Stehr, Sonja Kallendrusch, Tobias Piegeler   +8 more
wiley   +1 more source

Requirements and Evaluation of Commercial Digital Light Processing 3D Printers for Upscaled Production of Microstructured Tissue Culture Devices

Advanced Engineering Materials, EarlyView.
Commercial light‐based 3D printers increasingly find use for industry‐scale production of microstructured tissue culture devices. How can commercial printer performance be assessed for a given application? This work introduces simplified quantitative metrics based on microstructural fidelity analysis, addressing key manufacturing challenges in scaling ...
Zoltán András Guller, Freja Høier, Rujing Zhang, Sandra Wilson, Niels B. Larsen   +4 more
wiley   +1 more source

Supplementary Table S16 from Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers

, 2023
Wei Zhou, Peng Fang, Dongan Yu, Hongyuan Ren, Meng You, Long Yin, Fei Mei, Huikai Zhu, Zhenzhen Wang, Hui Xu, Yuxia Cao, Xiaowei Sun, Xiaohong Xu, Jianjun Bi, Jin Wang, Lanping Ma, Xin Wang, Lin Chen, Yongliang Zhang, Xiaowei Cen, Xi Zhu, Liguang Lou, Datao Liu, Xiaoding Tan, Jinliang Yang, Tao Meng, Jingkang Shen   +26 more
openalex   +1 more source

Preclinical PET imaging of glycoprotein non-metastatic melanoma B in triple negative breast cancer: Feasibility of an antibody-based companion diagnostic agent [PDF]

, 2017
Dehdashti, Farrokh, Hawthorne, Thomas, Hoog, Jeremy, Hyrc, Krzysztof, Keler, Tibor, Laforest, Richard, Lapi, Suzanne E, Lee, Supum, Li, Shunqiang, Ma, Cynthia X, Marquez-Nostra, Bernadette V, Nie, Xingyu, Vitale, Laura   +12 more
core   +2 more sources