Results 81 to 90 of about 918,699 (241)

ADVANCED PRECLINICAL MODELS FOR EVALUATION OF DRUG INDUCED LIVER INJURY - CONSENSUS STATEMENT BY THE EUROPEAN DRUG-INDUCED LIVER INJURY NETWORK [PRO-EURO-DILI-NET].

Journal of Hepatology, 2021
J. Fernández-Checa, P. Bagnaninchi, Hui-hui Ye, P. Sancho-Bru, J. Falcón-Pérez, F. Royo, C. Garcia-Ruiz, O. Konu, J. Miranda, O. Lunov, A. Dejneka, A. Elfick, A. McDonald, G. Sullivan, G. Aithal, M. Lucena, R. Andrade, B. Fromenty, M. Kranendonk, F. Cubero, Leonard J. Nelson   +20 more
semanticscholar   +1 more source

Book Review: Histopathology of Preclinical Toxicity Studies, Fourth Edition: Interpretation and Relevance in Drug Safety Evaluation [PDF]

, 2012
JM Ward
openalex   +1 more source

Preclinical evaluation of the immunomodulatory lymphocyte trafficking drug FTY720 for HIV prevention in the female genital mucosa of macaques [PDF]

, 2014
Monica Morris, Rachael D. Aubert, Katherine Butler, Tara Henning, James Mitchell, Leecresia Jenkins, David A. Garber, Janet M. McNicholl, Ellen N. Kersh   +8 more
openalex   +1 more source

PM288. Preclinical Evaluation of Neutral Cannabinoid CB1 Receptor Antagonists and Cannabinoid CB1 Receptor Negative Allosteric Modulators for Treating Drug Addiction [PDF]

, 2016
Eliot L. Gardner, Guo‐Hua Bi, Ganesh A. Thakur, Alexandros Makriyannis, Herbert H. Seltzman, Xianghu He, Zheng‐Xiong Xi   +6 more
openalex   +1 more source

In silico predictions of drug-induced changes in human cardiac contractility align with experimental recordings

Frontiers in Pharmacology
Drug-induced changes in cardiac contractility (inotropy) can lead to cardiotoxicity, a major cause of discontinuation in drug development. Preclinical approaches to assess cardiac inotropy are imperfect, with in vitro assays limited to stem cell-derived ...
Cristian Trovato, Cristian Trovato, Stefano Longobardi, Elisa Passini, Kylie A. Beattie, Maxx Holmes, Khuram W. Chaudhary, Eric I. Rossman, Blanca Rodriguez   +8 more
doaj   +1 more source

Supplementary Tables S1-4 from Design and Preclinical Evaluation of a Novel B7-H4–Directed Antibody–Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305

, 2023
Krista Kinneer, Philipp Wortmann, Zachary A. Cooper, Niall J. Dickinson, Luke A. Masterson, Thais Cailleau, Ian Hutchinson, Balakumar Vijayakrishnan, Mary McFarlane, Kathryn Ball, Michael Davies, Arthur Lewis, Yue Huang, Anton I. Rosenbaum, Jiaqi Yuan, Jon Chesebrough, Judith Anderton, Noel R. Monks, Steven Novick, Jixin Wang, Nazzareno Dimasi, R. James Christie, Darrin Sabol, Frances Anne Tosto, Yann Wallez, Elisabetta Leo, Mark R. Albertella, Anna D. Staniszewska, David A. Tice, Philip W. Howard, Nadia Luheshi, Puja Sapra   +31 more
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Evaluation of Aerosol Delivery of Nanosuspension for Pre-clinical Pulmonary Drug Delivery

Nanoscale Research Letters, 2009
Asthma and chronic obstructive pulmonary disease (COPD) are pulmonary diseases that are characterized by inflammatory cell infiltration, cytokine production, and airway hyper-reactivity. Most of the effector cells responsible for these pathologies reside
Chiang Po-Chang, Alsup Jason, Lai Yurong, Hu Yiding, Heyde Bruce, Tung David   +5 more
doaj   +1 more source

Supplementary Figures S11-18 from Design and Preclinical Evaluation of a Novel B7-H4–Directed Antibody–Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305

, 2023
Krista Kinneer, Philipp Wortmann, Zachary A. Cooper, Niall J. Dickinson, Luke A. Masterson, Thais Cailleau, Ian Hutchinson, Balakumar Vijayakrishnan, Mary McFarlane, Kathryn Ball, Michael Davies, Arthur Lewis, Yue Huang, Anton I. Rosenbaum, Jiaqi Yuan, Jon Chesebrough, Judith Anderton, Noel R. Monks, Steven Novick, Jixin Wang, Nazzareno Dimasi, R. James Christie, Darrin Sabol, Frances Anne Tosto, Yann Wallez, Elisabetta Leo, Mark R. Albertella, Anna D. Staniszewska, David A. Tice, Philip W. Howard, Nadia Luheshi, Puja Sapra   +31 more
openalex   +1 more source

41P Evaluation of ARX517: A next-generation anti-PSMA antibody drug conjugate for prostate cancer treatment, in preclinical enzalutamide-resistant and enzalutamide-sensitive pharmacology models and in toxicology models [PDF]

, 2023
Xiaofeng Zhang, D. Mills, Jin‐Ock Kim, N. Knudsen, Jay A. Nelson, Ying Buechler, Lillian Skidmore   +6 more
openalex   +1 more source

ANALYTICAL REVIEW OF THE NORMATIVE BASE TO PROVIDE THE GOOD QUALITY OF PRECLINICAL STUDIES IN RUSSIA

Разработка и регистрация лекарственных средств, 2019
The main goal of preclinical studiesis the development of effective, high-quality and safe drugs. The task of preclinical studiesis to obtain exhaustive information, reliable and reproducible results.
A. I. Selezneva, S. V. Glembotsky, S. V. Polyakov, M. N. Makarova, V. G. Makarov, A. A. Churin   +5 more
doaj