Results 91 to 100 of about 192,321 (310)
The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds [PDF]
, 2012 Despite rigorous preclinical and clinical safety evaluation, adverse cardiac effects remain a leading cause of drug attrition and post-approval drug withdrawal. A number of cardiovascular screens exist within preclinical development. These screens do not,
Borland, Samantha +8 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
First-generation and preclinical evaluation of an EphA5-targeted antibody-drug conjugate in solid tumors [PDF]
Contemporary cancer treatment strategies are shifting toward targeted therapies to improve efficacy and minimize toxicity. Here, we report the design and preclinical evaluation of MBRC-101, a first-in-class antibody-drug conjugate (ADC) targeting EphA5 ...
Christopher Markosian +13 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Preclinical characterisation of fingolimod as a potential therapeutic agent for stroke [PDF]
, 2022 Stroke is the leading cause for death and disability worldwide, and the search for novel drug treatments has been affected by repeated clinical trial failures.
Diaz Diaz, Andrea C.
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Human skin-on-a-chip for mpox pathogenesis studies and preclinical drug evaluation. [PDF]
Trends Pharmacol Sci, 2023 Zhu J, Abaci HE.
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Preclinical Evaluation of Drug Delivery Systems for Immunotherapy [PDF]
, 2019 Cancer is among the leading causes of global deaths. This is despite significant advances in cancer treatment and understanding where especially immunotherapy has shown promising results in recent years.
Christensen, Esben
core
Animal Models and Experimental MedicineHuman‐derived tumor models are essential for preclinical development of new anticancer drug entities. Generating animal models bearing tumors of human origin, such as patient‐derived or cell line–derived xenograft tumors, is dependent on immunodeficient ...
Seyed Mostafa Monzavi +4 more
doaj +1 more source