Results 81 to 90 of about 7,203,066 (311)

Image-guided drug delivery : preclinical applications and clinical translation [PDF]

, 2015
Image-guided drug delivery refers to the combination of drug targeting and imaging. Preclinically, image-guided drug delivery can be used for several different purposes, including for monitoring biodistribution, target site accumulation, off-target ...
Kiessling, Fabian, Ojha, Tarun, Pharmaceutics, Storm, Gerrit, Lammers, Twan, Lammers, Twan Gerardus Gertudis Maria, Sub Drug targeting, Sub General Pharmaceutics, Storm, G, Storm, Gert, Rizzo, Larissa   +10 more
core   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

DRLS, drug establishment registration and drug listing instruction booklet.

, 1991
Shipping list no.: 91-422-P.At head of title: DRLS, Drug Registration and Listing System.Mode of access ...
Center for Drug Evaluation and Research (U.S.). Drug Listing Branch.
core  

External review of the IDRC Evaluation Unit [PDF]

, 2010
French version available in IDRC Digital Library: Constatations en bref de l'examen externe de la Section de l'évaluation du CRDIThis brief is based on the "Report on the 2010 External Review of the IDRC Evaluation Unit" by Ailish Byrne, Ian C.
IDRC. Evaluation Unit
core   +1 more source

Preclinical pharmacokinetic evaluation of novel antimalarial and antituberculosis drug leads [PDF]

, 2019
Preclinical pharmacokinetics relies on efficient and accurate screening to select clinical candidates from early leads. Poor pharmacokinetic interpretation can disadvantage drug discovery by promoting inadequate compounds and expelling potential drug ...
Strydom, Natasha
core   +1 more source

Mechanisms of Cell Death Induced by Cannabidiol Against Tumor Cells: A Review of Preclinical Studies

Plants
Commonly known as marijuana or hemp, Cannabis sativa L. (Cannabaceae), contains numerous active compounds, particularly cannabinoids, which have been extensively studied for their biological activities.
Edilene S. A. Melo, Estefani A. Asevedo, Joaquim Maurício Duarte-Almeida, Fahrul Nurkolis, Rony Abdi Syahputra, Moon Nyeo Park, Bonglee Kim, Renê Oliveira do Couto, Rosy Iara Maciel de A. Ribeiro   +8 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Supplementary Figure from Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody–drug Conjugate Targeting ADAM9-expressing Tumors

, 2022
Supplementary Figure from Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody–drug Conjugate Targeting ADAM9-expressing ...
Jeff Hooley (15084369), Ying Li (15092440), Richard J. Gregory (15092479), Stuart W. Hicks (15092404), Marian Themeles (15092434), Jacquelynn Lucas (15092419), Kerstin W. Sinkevicius (15092407), Kerry A. McEachem (15092464), Nicholas C. Yoder (15092410), Valentina Ciccarone (15092461), Sergey Gorlatov (15092455), Paul A. Moore (15092473), Deryk Loo (15092485), Megan E. Fuller (15092422), Thomas Son (15092425), Lusiana Widjaja (15092452), Olga Ab (15087715), Thomas Chittenden (15092476), Francine Z. Chen (15092437), James Tamura (15092458), Bhaswati Barat (15092449), Scott Koenig (15092467), Michael Chiechi (15092443), Christopher Espelin (15092431), Jennifer G. Brown (15092416), Gundo Diedrich (15092413), Juniper A. Scribner (15092401), Jenny Lee (15092446), Ezio Bonvini (15092482), Anahita Dastur (15092428), Eric H. Westin (15092470)   +30 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Human skin-on-a-chip for mpox pathogenesis studies and preclinical drug evaluation. [PDF]

Trends Pharmacol Sci, 2023
Zhu J, Abaci HE.
europepmc   +1 more source