Results 111 to 120 of about 6,725,081 (364)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Breast-Lesion Characterization using Textural Features of Quantitative Ultrasound Parametric Maps [PDF]

, 2017
© 2017 The Author(s). This study evaluated, for the first time, the efficacy of quantitative ultrasound (QUS) spectral parametric maps in conjunction with texture-analysis techniques to differentiate non-invasively benign versus malignant breast lesions.
A Ahmed, A Heindl, A König, A Sadeghi-Naini, A Sadeghi-Naini, A Sadeghi-Naini, A Sadeghi-Naini, A Sadeghi-Naini, A Sadeghi-Naini, AV Alvarenga, B Sigel, D Sengupta, E Feleppa, EJ Feleppa, EJ Feleppa, EJ Feleppa, EJ Feleppa, EJ Feleppa, F Davnall, FL Lizzi, FL Lizzi, FLL Lizzi, H Tadayyon, H Tadayyon, H Tadayyon, H Tadayyon, J Mamou, JPB O’Connor, K Polyak, KA Wear, KA Wear, KC Balaji, L Sannachi, LX Yao, M Vaidya, MJ Gerdes, ML Oelze, ML Oelze, ML Oelze, ML Oelze, ML Oelze, N Duric, N Sannomiya, R Natrajan, RJ Lavarello, RL Siegel, RM Haralick, S Chicklore, S Tan, T Cover, T Noritomi, TJ Larkin, V Goh, Y Labyed, Y Labyed, Y-Y Liao   +55 more
core   +2 more sources

Gelatin-based Hydrogel Degradation and Tissue Interaction in vivo: Insights from Multimodal Preclinical Imaging in Immunocompetent Nude Mice

Theranostics, 2016
Hydrogels based on gelatin have evolved as promising multifunctional biomaterials. Gelatin is crosslinked with lysine diisocyanate ethyl ester (LDI) and the molar ratio of gelatin and LDI in the starting material mixture determines elastic properties of ...
C. Tondera, S. Hauser, A. Krüger-Genge, F. Jung, A. Neffe, A. Lendlein, R. Klopfleisch, J. Steinbach, Christin Neuber, Jens Pietzsch   +9 more
semanticscholar   +1 more source

Diffusion Tensor Imaging in Preclinical Huntington’s Disease [PDF]

Brain Imaging and Behavior, 2008
Diffusion tensor imaging was used to study brain related changes in white matter that may be associated with Huntington's Disease progression. Thirty-one preclinical gene-mutation carriers were imaged cross-sectionally using diffusion tensor and anatomical brain imaging.
Magnotta, Vincent A., Kim, Jinsuh, Koscik, Tim, Beglinger, Leigh J., Espinso, Daisy, Langbehn, Doug, Nopoulos, Peg, Paulsen, Jane S.   +7 more
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Preclinical imaging of the co-stimulatory molecules CD80 and CD86 with indium-111-labeled belatacept in atherosclerosis

EJNMMI Research, 2016
BackgroundThe inflammatory nature of atherosclerosis provides a broad range of potential molecular targets for atherosclerosis imaging. Growing interest is focused on targets related to plaque vulnerability such as the co-stimulatory molecules CD80 and ...
Romana Meletta, Adrienne Müller Herde, Patrick Dennler, E. Fischer, R. Schibli, S. Krämer   +5 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Assessing PET performance, image quality, and attenuation correction in the presence of RF coils within a 9.4 T MRI for preclinical simultaneous imaging

EJNMMI Physics
Background This study evaluates the performance of a positron emission tomography (PET) insert combined with a 9.4 Tesla magnetic resonance (MR) imaging system using three different radiofrequency (RF) coils.
Claudia Kuntner, Joachim Friske, Andrea Stessl, Martin Haas, Lara Luna Breyer, Thomas Wanek, Marcus Hacker, Thomas Helbich, Ivo Rausch   +8 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Assessment of [¹²⁵I]a-Bungarotoxin Binding to a7 Nicotinic Acetylcholinergic Receptors in Hippocampus-Subiculum of Postmortem Human Parkinson’s Disease Brain

Biomolecules
Parkinson’s disease (PD) involves motor and cognitive impairment that nicotinic acetylcholine receptors (nAChRs) such as the α7 subtype are responsible for regulating.
Fariha Karim, Allyson Ngo, Titus E. Tucker, Ashlee D. L. Coronel, Jogeshwar Mukherjee   +4 more
doaj   +1 more source