Results 91 to 100 of about 2,109,805 (291)

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Radioiodinated Tau Imaging Agent III Molecular Modeling, Synthesis, and Evaluation of a New Tau Imaging Agent, [¹²⁵I]ISAS in Post-Mortem Human Alzheimer’s Disease Brain

Molecules
Using a molecular modeling approach for Tau-binding sites, we modified our previously reported imaging agent, [125I]INFT, for the potential improvement of binding properties to Tau in an Alzheimer’s disease (AD) brain.
Stephanie A. Sison, Cayz G. Paclibar, Christopher Liang, Jogeshwar Mukherjee   +3 more
doaj   +1 more source

HLMiller-Imaging/SlowMembraneDiffusionAnalysis: Version 1

<h2>What's Changed</h2> <ul> <li>Addcode by @HLMiller-Imaging in https://github.com/HLMiller-Imaging/SlowMembraneDiffusionAnalysis/pull/1</li> <li>TrajectoryBugFix by @HLMiller-Imaging in https://github.com/HLMiller ...
HLMiller-Imaging
core   +1 more source

Comparative Analysis of Ultrasonography and MicroCT Imaging for Organ Size Evaluation in Mice [PDF]

In this work, the authors compared microCT and in vivo ultrasonography in terms of accuracy and efficacy for measuring the volume of various organs in mice.
Juan Jose Jimenez Catalan, Ferrer Clotas, Marina, Marina Ferrer Clotas, Juan Antonio Camara Serrano, Catalan, Juan Jose Jimenez, Serrano, Juan Antonio Camara, Cámara Serrano, Juan Antonio, Jiménez Catalán, Juan José, Clotas, Marina Ferrer   +8 more
core   +1 more source

Standardization of Preclinical PET/CT Imaging to Improve Quantitative Accuracy, Precision, and Reproducibility:A Multicenter Study [PDF]

, 2019
Preclinical PET/CT is a well-established noninvasive imaging tool for studying disease development/progression and the development of novel radiotracers and pharmaceuticals for clinical applications.
Welch, A, Mingarelli, M, Schneider, JE, Tavares, Adriana A. S., Vanhove, C, Lewellen, B, Corral, Carlos Alcaide, Tavares, Adriana, Newby, David, Mcdougald, Wendy, Vandenberghe, S, Mingarelli, Marco, Lehnert, Adrienne, Tavares, AAS, Corral, Carlos, Welch, Andy, Schneider, Jurgen, McDougald, W, Newby, DE, Wright, John, Plein, S, Lewellen, Barbara, Miyaoka, Robert, Schneider, Jurgen E., Tavares, Adriana Alexandre S., Lehnert, A, Miyaoka, R, Corral, CA, Plein, Sven, Vandenberghe, Stefaan, Wright, J, Vanhove, Christian   +31 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Digital Imaging Program fact sheet

, 2004
Title from PDF caption (viewed May 11, 2007).; "January 2004."; Previously issued: Fact sheet / Digital Imaging Program. [Hartford] : State of Connecticut, Dept. of Social Services, [1996]
Digital Imaging Program (Conn.)
core   +1 more source