Results 111 to 120 of about 2,109,805 (291)

Preclinical progression of neurodegenerative diseases [PDF]

, 2018
2018-08Neurodegenerative diseases are disorders that are characterized by a progressive decline of the motor and/or cognitive function caused by a selective loss of neurons within the central nervous system.
Hashizume, Atsushi, Sahashi, Kentaro, Katsuno, Masahisa, Iguchi, Yohei   +3 more
core   +1 more source

Mapping serotonergic dynamics using drug-modulated molecular connectivity in rats

eLife
Understanding the complex workings of the brain is one of the most significant challenges in neuroscience, providing insights into normal brain function, neurological diseases, and the effects of potential therapeutics.
Tudor M Ionescu, Mario Amend, Rakibul Hafiz, Andreas Maurer, Bharat Biswal, Hans F Wehrl, Kristina Herfert   +6 more
doaj   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Noninvasive in vivo imaging of NF-κB activation predicts immunotherapy response in solid tumors

npj Imaging
Cancer immunotherapy improves survival, yet many patients exhibit primary or acquired resistance. We established a combinatorial immunotherapy (COMBO) consisting of tumor antigen-specific Th1 cells and dual immune checkpoint blockade and aimed to ...
Dimitri Stowbur, Roman Mehling, Philipp Knopf, Barbara Francisca Schörg, Dominik Sonanini, Danielle Arnold-Schild, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Birgit Fehrenbacher, Martin Schaller, Harald Carlsen, Snehlata Kumari, Bernd Jürgen Pichler, Manfred Kneilling   +13 more
doaj   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

PRECLINICAL IMAGING FACILITY-IBB website

, 2018
Preclinical imaging has become a powerful tool in biomedical research, allowing the non-invasive detection of biomarkers of disease. It enables the collection of anatomical, functional and dynamic imaging data from living experimental animals, including ...
Sara Gargiulo
core  

Minimizing near-infrared autofluorescence in preclinical imaging with diet and wavelength selection. [PDF]

J Biomed Opt, 2023
Sun Y, Zhong X, Dennis AM.
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Disruption of normal brain distribution of [18F]Nifene to α4β2* nicotinic acetylcholinergic receptors in old B6129SF2/J mice and transgenic 3xTg-AD mice model of Alzheimer's disease: In Vivo PET/CT imaging studies

NeuroImage
The 3xTg-AD transgenic mouse model develops Aβ plaque and tau pathology and is purported to closely resemble pathological development in the human Alzheimer's disease (AD) brain.
Christopher Liang, Atsumi A. Okamoto, Fariha Karim, Shimako Kawauchi, Lusine Melkonyan, Tram B. Danh, Jogeshwar Mukherjee   +6 more
doaj   +1 more source