Results 1 to 10 of about 100,027 (160)

Whole-Body Autoradiography [PDF]

Journal of Histochemistry and Cytochemistry, 1981
Ever since its introduction in the early 1950s whole-body autoradiography has been used quite extensively for mapping the fate of various substances in the body, especially in the fields of pharmacology and toxicology. A detailed description of the whole-body autoradiographic technique is given.
Sven Ullberg
exaly   +5 more sources

Interactive impacts of social deprivation and intranasal oxytocin administration on oxytocin receptor density in prairie vole brains [PDF]

Frontiers in Behavioral Neuroscience
IntroductionEarly-life social experiences have a profound impact on the development of the brain and behavior. Previous work has shown that prairie voles (Microtus ochrogaster) raised in a socially limited environment (raised by a single mother and ...
Susanna Zheng, George S. Prounis, Alexander G. Ophir   +2 more
doaj   +2 more sources

Autoradiography [PDF]

Ca-A Cancer Journal for Clinicians, 1958
P J Fitzgerald
exaly   +5 more sources

Superiority of Formalin-Fixed Paraffin-Embedded Brain Tissue for in vitro Assessment of Progressive Supranuclear Palsy Tau Pathology With [18F]PI-2620

Frontiers in Neurology, 2021
Objectives: Autoradiography on brain tissue is used to validate binding targets of newly discovered radiotracers. The purpose of this study was to correlate quantification of autoradiography signal using the novel next-generation tau positron emission ...
Marie Willroider, Sigrun Roeber, Anja K. E. Horn, Thomas Arzberger, Thomas Arzberger, Maximilian Scheifele, Gesine Respondek, Osama Sabri, Henryk Barthel, Marianne Patt, Olena Mishchenko, Andreas Schildan, André Mueller, Norman Koglin, Andrew Stephens, Johannes Levin, Johannes Levin, Johannes Levin, Günter U. Höglinger, Günter U. Höglinger, Günter U. Höglinger, Günter U. Höglinger, Peter Bartenstein, Peter Bartenstein, Jochen Herms, Jochen Herms, Matthias Brendel, Matthias Brendel, Leonie Beyer, Leonie Beyer   +29 more
doaj   +1 more source

Down-Regulation of Toll-Like Receptor 5 (TLR5) Increased VEGFR Expression in Triple Negative Breast Cancer (TNBC) Based on Radionuclide Imaging

Frontiers in Oncology, 2021
In this study, GFP-tagged TNBC 4T1 cells with down-regulated TLR5 expression (TLR5− 4T1) and normal TLR5 expression (TLR5+ 4T1) were constructed, respectively.
Wen Jiang, Yeming Han, Ting Liang, Chao Zhang, Feng Gao, Guihua Hou   +5 more
doaj   +1 more source

Design, Synthesis, and Validation of a Novel [¹¹C]Promethazine PET Probe for Imaging Abeta Using Autoradiography

Molecules, 2021
Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer’s disease.
Clayton A. Whitmore, Mariam I. Boules, William J. Behof, Justin R. Haynes, Dmitry Koktysh, Adam J. Rosenberg, Mohammed N. Tantawy, Wellington Pham   +7 more
doaj   +1 more source

Nuclear Melt Glass from Experimental Field, Semipalatinsk Test Site

Energies, 2022
Investigation of shocked materials provides unique information about behavior of substances in extreme thermodynamic conditions. Near surface nuclear tests have induced multiple transformations of affected soils. Examination of nuclear glasses and relics
Irina E. Vlasova, Vasily O. Yapaskurt, Alexei A. Averin, Oleg E. Melnik, Denis A. Zolotov, Roman A. Senin, Tatiana R. Poliakova, Iurii M. Nevolin, Stepan N. Kalmykov, Andrey A. Shiryaev   +9 more
doaj   +1 more source

The Role of Dopamine in the Stimulant Characteristics of Novel Psychoactive Substances (NPS)—Neurobiological and Computational Assessment Using the Case of Desoxypipradrol (2-DPMP)

Frontiers in Pharmacology, 2020
Stimulant drugs, including novel psychoactive substances (NPS, formerly “legal highs”) have addictive potential which their users may not realize. Stimulants increase extracellular dopamine levels in the brain, including the reward and addiction pathways,
Barbara Loi, Barbara Loi, Michelle A. Sahai, Maria Antonietta De Luca, Hana Shiref, Jolanta Opacka-Juffry   +5 more
doaj   +1 more source

High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling

Frontiers in Public Health, 2023
BackgroundPrevious research has outlined the health benefits of exercise including its therapeutic potential for substance use disorders (SUD). These data have already been utilized and it is now common to find exercise as part of SUD treatment and ...
John Tyler, John Tyler, Madeline Podaras, Madeline Podaras, Brittany Richardson, Brittany Richardson, Nicole Roeder, Nicole Roeder, Nikki Hammond, John Hamilton, Kenneth Blum, Mark Gold, David A. Baron, Panayotis K. Thanos, Panayotis K. Thanos   +14 more
doaj   +1 more source

Radiosynthesis and Preclinical Evaluation of an ¹⁸F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A)

Pharmaceuticals, 2022
The cyclic nucleotide phosphodiesterase 2A is an intracellular enzyme which hydrolyzes the secondary messengers cAMP and cGMP and therefore plays an important role in signaling cascades.
Barbara Wenzel, Stefan R. Fritzsche, Magali Toussaint, Detlef Briel, Klaus Kopka, Peter Brust, Matthias Scheunemann, Winnie Deuther-Conrad   +7 more
doaj   +1 more source