Results 21 to 30 of about 100,048 (180)

In Vitro and In Vivo Characterization of Dibenzothiophene Derivatives [¹²⁵I]Iodo-ASEM and [¹⁸F]ASEM as Radiotracers of Homo- and Heteromeric α7 Nicotinic Acetylcholine Receptors

Molecules, 2020
The α7 nicotinic acetylcholine receptor (α7 nAChR) is involved in several cognitive and physiologic processes; its expression levels and patterns change in neurologic and psychiatric diseases, such as schizophrenia and Alzheimer’s disease,
Cornelius K. Donat, Henrik H. Hansen, Hanne D. Hansen, Ronnie C. Mease, Andrew G. Horti, Martin G. Pomper, Elina T. L’Estrade, Matthias M. Herth, Dan Peters, Gitte M. Knudsen, Jens D. Mikkelsen   +10 more
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The Periodic Replacement of Adhesive Setae in Pad Lamellae of Climbing Lizards Is Driven by Patterns of Corneous Layer Growth

Journal of Developmental Biology, 2022
The adhesive digital pads in some gecko and anoline lizards are continuously utilized for movements on vertical surfaces that may determine wear and a decrease of adhesion efficiency.
Lorenzo Alibardi
doaj   +1 more source

Amyloid-Targeting PET Tracer [18F]Flutemetamol Accumulates in Atherosclerotic Plaques

Molecules, 2019
Atherosclerosis is characterized by the accumulation of oxidized lipids in the artery wall, which triggers an inflammatory response. Oxidized low-density lipoprotein (ox-LDL) presents amyloid-like structural properties, and different amyloid species have
Sanna Hellberg, Johanna M.U. Silvola, Heidi Liljenbäck, Max Kiugel, Olli Eskola, Harri Hakovirta, Sohvi Hörkkö, Veronique Morisson-Iveson, Ella Hirani, Pekka Saukko, Seppo Ylä-Herttuala, Juhani Knuuti, Antti Saraste, Anne Roivainen   +13 more
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Penetration, distribution, and elimination of remofuscin/soraprazan in Stargardt mouse eyes following a single intravitreal injection using pharmacokinetics and transmission electron microscopic autoradiography: Implication for the local treatment of Stargardt’s disease and dry age‐related macular degeneration

Pharmacology Research & Perspectives, 2020
Age‐related macular degeneration (AMD) is the leading cause of blindness in older people in the developed world while Stargardt's disease (SD) is a juvenile macular degeneration and an orphan disease.
Sylvie Julien‐Schraermeyer, Barbara Illing, Alexander Tschulakow, Tatjana Taubitz, Jamil Guezguez, Michael Burnet, Ulrich Schraermeyer   +6 more
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α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson’s Disease

Biomedicines, 2021
Progressive degeneration of dopaminergic neurons, immune activation, and α-synuclein pathology characterize Parkinson’s disease (PD). We previously reported that unilateral intranigral injection of recombinant adeno-associated viral (rAAV) vectors ...
Kathrine Stokholm, Majken Borup Thomsen, Jenny-Ann Phan, Line K. Møller, Cecilie Bay-Richter, Søren H. Christiansen, David P. D. Woldbye, Marina Romero-Ramos, Anne M. Landau   +8 more
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In Vitro and In Vivo Characterization of Selected Fluorine-18 Labeled Radioligands for PET Imaging of the Dopamine D3 Receptor

Molecules, 2016
Cerebral dopamine D3 receptors seem to play a key role in the control of drug-seeking behavior. The imaging of their regional density with positron emission tomography (PET) could thus help in the exploration of the molecular basis of drug addiction.
Natascha Nebel, Simone Maschauer, Torsten Kuwert, Carsten Hocke, Olaf Prante   +4 more
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Radionuclides contamination of leaves of woody plants growing within the CHNPP cooling pond [PDF]

Ядерна фізика та енергетика, 2021
The data on the state of radioactive contamination of leaves of plants growing directly on the territory of the drained part of the cooling pond of the Chernobyl NPP are presented.
V. K. Shynkarenko, S. A. Paskevych, Y. A. Menshenin, O. O. Odintsov   +3 more
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Alterations in Cerebral Blood Flow and Glucose Utilization in Mice Overexpressing the Amyloid Precursor Protein

Neurobiology of Disease, 2002
We have used quantitative autoradiographic techniques to study the relationship between cerebral blood flow (CBF) and glucose utilization (CGU) in two lines of transgenic mice overexpressing Swedish mutant amyloid precursor protein (APP) and APP-derived ...
Kiyoshi Niwa, Ken Kazama, Steven G. Younkin, George A. Carlson, Costantino Iadecola   +4 more
doaj   +1 more source

Decreased MK-801 Binding in Discrete Hippocampal Regions of Prion-Infected Mice

Neurobiology of Disease, 2001
The neurochemical alterations associated with neurodegeneration in prion diseases are not well defined. It is therefore of interest to study the influence of prion infection on messenger molecules and their receptors.
M. Diez, S.J. DeArmond, D. Groth, S.B. Prusiner, T. Hökfelt   +4 more
doaj   +1 more source

Reduced Metabotropic Glutamate Receptor Type 5 Availability in the Epileptogenic Hippocampus: An in vitro Study

Frontiers in Neurology, 2022
Abnormalities in the expression of metabotropic glutamate receptor type 5 (mGluR5) have been observed in the hippocampus of patients with drug-resistant mesial Temporal Lobe Epilepsy (mTLE).
Maria Zimmermann, Maria Zimmermann, Luciano Minuzzi, Luciano Minuzzi, Arturo Aliaga Aliaga, Arturo Aliaga Aliaga, Marie-Christine Guiot, Jeffery A. Hall, Jean-Paul Soucy, Jean-Paul Soucy, Gassan Massarweh, Salah El Mestikawy, Pedro Rosa-Neto, Pedro Rosa-Neto, Eliane Kobayashi   +14 more
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