Results 71 to 80 of about 231,020 (192)

Multimodality Imaging of Tumour Pathophysiology and Response to Pharmacological Intervention

, 2015
This thesis describes the need for imaging the tumour pathophysiological microenvironment in order to understand response to treatment. Specifically looking at tumour vascularisation in in vivo murine xenograft models of disease, response to treatment ...
Johnson, SP
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Sigma receptor ligands: novel applications in cancer imaging and treatment [PDF]

, 2012
Sigma receptoren (subtypes sigma-1 en sigma-2) zijn unieke bindingsplaatsen die een aanzienlijk hogere expressie vertonen in kanker dan in gezond weefsel.
Rybczynska, Anna A.,, Rybczynska, Anna A.   +1 more
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Comparative Analysis of Ultrasonography and MicroCT Imaging for Organ Size Evaluation in Mice [PDF]

In this work, the authors compared microCT and in vivo ultrasonography in terms of accuracy and efficacy for measuring the volume of various organs in mice.
Juan Jose Jimenez Catalan, Ferrer Clotas, Marina, Marina Ferrer Clotas, Juan Antonio Camara Serrano, Catalan, Juan Jose Jimenez, Serrano, Juan Antonio Camara, Cámara Serrano, Juan Antonio, Jiménez Catalán, Juan José, Clotas, Marina Ferrer   +8 more
core   +1 more source

Radioiodinated Tau Imaging Agent III Molecular Modeling, Synthesis, and Evaluation of a New Tau Imaging Agent, [¹²⁵I]ISAS in Post-Mortem Human Alzheimer’s Disease Brain

Molecules
Using a molecular modeling approach for Tau-binding sites, we modified our previously reported imaging agent, [125I]INFT, for the potential improvement of binding properties to Tau in an Alzheimer’s disease (AD) brain.
Stephanie A. Sison, Cayz G. Paclibar, Christopher Liang, Jogeshwar Mukherjee   +3 more
doaj   +1 more source

Preclinical Molecular Imaging for Precision Medicine in Breast Cancer Mouse Models [PDF]

, 2019
Precision and personalized medicine is gaining importance in modern clinical medicine, as it aims to improve diagnostic precision and to reduce consequent therapeutic failures. In this regard, prior to use in human trials, animal models can help evaluate
Salvatore M., Meomartino L, Fatone G, Salvatore M, Greco A, Meomartino L., Fiordelisi MF, Auletta L., Fiordelisi M. F., Basso L, Mancini M, Fatone G., Auletta L, Basso L., Mancini M., Greco A.   +15 more
core   +1 more source

[¹⁸F]Mefway: Imaging Serotonin 5HT_1A Receptors in Human Postmortem Alzheimer’s and Parkinson’s Disease Anterior Cingulate. Potential Applications to Human Positron Emission Tomography Studies

Biomolecules
Serotonin 5HT1A receptors may be affected in neurodegeneration, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Using the selective 5HT1A receptor positron emission tomography (PET) imaging agent, [18F]mefway, autoradiographic studies from
Noresa L. Gonzaga, Fariha Karim, Christopher Liang, Jogeshwar Mukherjee   +3 more
doaj   +1 more source

Preclinical molecular imaging: from the laboratory bench to the patient.

, 2015
Preclinical molecular imaging plays a key role in the study of diseases and the development – evaluation - validation of novel treatments and diagnostic techniques.
Plenevaux, Alain
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Development and Successful Validation of Simple and Fast TLC Spot Tests for Determination of Kryptofix® 2.2.2 and Tetrabutylammonium in 18F-Labeled Radiopharmaceuticals

Pharmaceuticals, 2014
Kryptofix® 2.2.2 (Kry) or tetrabutylammonium (TBA) are commonly used as phase transfer catalysts in 18F-radiopharmaceutical productions for positron emission tomography (PET).
Matthias Kuntzsch, Denis Lamparter, Nils Brüggener, Marco Müller, Gabriele J. Kienzle, Gerald Reischl   +5 more
doaj   +1 more source

Magnetic particle imaging: from proof of principle to preclinical applications

, 2017
Tomographic imaging has become a mandatory tool for the diagnosis of a majority of diseases in clinical routine. Since each method has its pros and cons, a variety of them is regularly used in clinics to satisfy all application needs.
Gdaniec, Nadine, Möddel, Martin, Knopp, Tobias   +2 more
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Mapping serotonergic dynamics using drug-modulated molecular connectivity in rats

eLife
Understanding the complex workings of the brain is one of the most significant challenges in neuroscience, providing insights into normal brain function, neurological diseases, and the effects of potential therapeutics.
Tudor M Ionescu, Mario Amend, Rakibul Hafiz, Andreas Maurer, Bharat Biswal, Hans F Wehrl, Kristina Herfert   +6 more
doaj   +1 more source