Results 51 to 60 of about 231,020 (192)

Elucidating the complementarity of resting-state networks derived from dynamic [18F]FDG and hemodynamic fluctuations using simultaneous small-animal PET/MRI

NeuroImage, 2021
Functional connectivity (FC) and resting-state network (RSN) analyses using functional magnetic resonance imaging (fMRI) have evolved into a growing field of research and have provided useful biomarkers for the assessment of brain function in ...
Tudor M. Ionescu, Mario Amend, Rakibul Hafiz, Bharat B. Biswal, Hans F. Wehrl, Kristina Herfert, Bernd J. Pichler   +6 more
doaj   +1 more source

Interregional compensatory mechanisms of motor functioning in progressing preclinical neurodegeneration.

, 2013
Understanding brain reserve in preclinical stages of neurodegenerative disorders allows determination of which brain regions contribute to normal functioning despite accelerated neuronal loss.
Scheller, Elisa, Peter, J, Peter, Jessica, Scheller, E., Peter, J., Abdulkadir, Ahmed, Frackowiak, Richard S. J., Frackowiak, R.S., Klöppel, Stefan, Tabrizi, S.J., Frackowiak, Richard S.J., Abdulkadir, A, Tabrizi, SJ, Frackowiak, RS, Scheller, E, Klöppel, S., Tabrizi, Sarah J., Abdulkadir, A., Klöppel, S   +18 more
core   +1 more source

Intratumoral in vivo staging of breast cancer by multi-tracer PET and advanced analysis

npj Breast Cancer, 2022
The staging and local management of breast cancer involves the evaluation of the extent and completeness of excision of both the invasive carcinoma component and also the intraductal component or ductal carcinoma in situ.
Jennifer Griessinger, Julian Schwab, Qian Chen, Anna Kühn, Jonathan Cotton, Gregory Bowden, Heike Preibsch, Gerald Reischl, Leticia Quintanilla-Martinez, Hidetoshi Mori, An Nguyen Dang, Ursula Kohlhofer, Olulanu H. Aina, Alexander D. Borowsky, Bernd J. Pichler, Robert D. Cardiff, Andreas M. Schmid   +16 more
doaj   +1 more source

Assessing the Functional Redundancy between P-gp and BCRP in Controlling the Brain Distribution and Biliary Excretion of Dual Substrates with PET Imaging in Mice

Pharmaceutics, 2021
P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are co-localized at the blood–brain barrier, where they display functional redundancy to restrict the brain distribution of dual P-gp/BCRP substrate drugs.
Irene Hernández-Lozano, Severin Mairinger, Alexander Traxl, Michael Sauberer, Thomas Filip, Johann Stanek, Claudia Kuntner, Thomas Wanek, Oliver Langer   +8 more
doaj   +1 more source

New Fully Automated Preparation of High Apparent Molar Activity ⁶⁸Ga-FAPI-46 on a Trasis AiO Platform

Molecules, 2022
A large number of applications for fibroblast activation protein inhibitors (FAPI)-based PET agents have been evaluated in conditions ranging from cancer to non-malignant diseases such as myocardial infarction. In particular, 68Ga-FAPI-46 was reported to
Chiara Da Pieve, Marta Costa Braga, David R. Turton, Frank A. Valla, Pinar Cakmak, Karl-Heinz Plate, Gabriela Kramer-Marek   +6 more
doaj   +1 more source

Spectral Imaging in Preclinical Research and Clinical Pathology [PDF]

, 2013
Spectral imaging methods are attracting increased interest from researchers and practitioners in basic science, preclinical and clinical arenas. A combination of better labeling reagents and better optics creates opportunities to detect and measure multiple parameters at the molecular and cellular level.
Levenson, Richard, Beechem, Joseph, McNamara, George   +2 more
openaire   +4 more sources

Evaluation of [18F]MK-6240 binding to tau protein in postmortem human brains of Down syndrome and Alzheimer’s disease and assessment of off-target (non-tau) binding

Acta Neuropathologica Communications
Alzheimer's disease (AD) and Down Syndrome (DS) are characterized by the aggregation of tau tangles. As a novel tau PET tracer in AD, [18F]MK-6240 has the potential in Down syndrome-associated Alzheimer’s disease (DSAD) to elucidate pathophysiology and ...
Fariha Karim, Agnes P. Biju, Christopher Liang, Camryn J. Santos, Maharishi Rajarethenam, Jogeshwar Mukherjee   +5 more
doaj   +1 more source

Western diet increases brain metabolism and adaptive immune responses in a mouse model of amyloidosis

Journal of Neuroinflammation
Diet-induced increase in body weight is a growing health concern worldwide. Often accompanied by a low-grade metabolic inflammation that changes systemic functions, diet-induced alterations may contribute to neurodegenerative disorder progression as well.
Marilena Poxleitner, Sabrina H. L. Hoffmann, Georgy Berezhnoy, Tudor M. Ionescu, Irene Gonzalez-Menendez, Florian C. Maier, Dominik Seyfried, Walter Ehrlichmann, Leticia Quintanilla-Martinez, Andreas M. Schmid, Gerald Reischl, Christoph Trautwein, Andreas Maurer, Bernd J. Pichler, Kristina Herfert, Nicolas Beziere   +15 more
doaj   +1 more source

Towards Imaging Tau Hyperphosphorylation: Is DYRK1A a Potential Target for Imaging Hyperphosphorylation of Tau? Molecular Modeling Assessment and Synthesis of [¹²⁵I]Radioiodinated DYRK1A Inhibitor

Molecules
Dual specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A), a phosphorylation kinase, is localized within the central nervous system and is linked to hyperphosphorylation of Tau.
Cayz G. Paclibar, Deanna M. Schafer, Agnes P. Biju, Fariha Karim, Stephanie A. Sison, Christopher Liang, Shamiha T. Ahmed, Jogeshwar Mukherjee   +7 more
doaj   +1 more source

Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors

Molecular Cancer, 2023
Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, programmed death-ligand 1 (PD-L1) expression
Philipp Knopf, Dimitri Stowbur, Sabrina H. L. Hoffmann, Natalie Hermann, Andreas Maurer, Valentina Bucher, Marilena Poxleitner, Bredi Tako, Dominik Sonanini, Balaji Krishnamachary, Sanhita Sinharay, Birgit Fehrenbacher, Irene Gonzalez-Menendez, Felix Reckmann, David Bomze, Lukas Flatz, Daniela Kramer, Martin Schaller, Stephan Forchhammer, Zaver M. Bhujwalla, Leticia Quintanilla-Martinez, Klaus Schulze-Osthoff, Mark D. Pagel, Marieke F. Fransen, Martin Röcken, André F. Martins, Bernd J. Pichler, Kamran Ghoreschi, Manfred Kneilling   +28 more
doaj   +1 more source