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3rd TPCF Preclinical Symposium Imaging(TPIS 2020)

Frontiers in Biomedical Technologies, 2020
The path of discovering/designing a molecule to developing a novel drug could take up to an average of 12 years and costs around $1 billion (USD). Preclinical phase is a major step on this path and is the part where scientists perform additional studies ...
3rd TPCF Preclinical Symposium Imaging (TPIS 2020)
doaj  

Elucidating the complementarity of resting-state networks derived from dynamic [18F]FDG and hemodynamic fluctuations using simultaneous small-animal PET/MRI

NeuroImage, 2021
Functional connectivity (FC) and resting-state network (RSN) analyses using functional magnetic resonance imaging (fMRI) have evolved into a growing field of research and have provided useful biomarkers for the assessment of brain function in ...
Tudor M. Ionescu, Mario Amend, Rakibul Hafiz, Bharat B. Biswal, Hans F. Wehrl, Kristina Herfert, Bernd J. Pichler   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Brain and Brown Adipose Tissue Metabolism in Transgenic Tg2576 Mice Models of Alzheimer Disease Assessed Using F-FDG PET Imaging

Molecular Imaging, 2017
Objective: Imaging animal models of Alzheimer disease (AD) is useful for the development of therapeutic drugs and understanding AD. Transgenic Swedish hAPPswe Tg2576 mice are a good model of β-amyloid plaques.
Robert A. Coleman PhD, Christopher Liang BS, Rima Patel BS, Sarah Ali BS, Jogeshwar Mukherjee PhD   +4 more
doaj   +1 more source

Acute and chronic inflammation alter immunometabolism in a cutaneous delayed-type hypersensitivity reaction (DTHR) mouse model

Communications Biology, 2022
Nuclear magnetic resonance spectroscopy-based tissue metabolomics is used to define detailed temporal signatures of acute and chronic inflammation in cutaneous delayed-type hypersensitivity reaction.
Laimdota Zizmare, Roman Mehling, Irene Gonzalez-Menendez, Caterina Lonati, Leticia Quintanilla-Martinez, Bernd J. Pichler, Manfred Kneilling, Christoph Trautwein   +7 more
doaj   +1 more source

[¹²⁴I]IBETA: A New Aβ Plaque Positron Emission Tomography Imaging Agent for Alzheimer’s Disease

Molecules, 2022
Several fluorine-18-labeled PET β-amyloid (Aβ) plaque radiotracers for Alzheimer’s disease (AD) are in clinical use. However, no radioiodinated imaging agent for Aβ plaques has been successfully moved forward for either single-photon emission computed ...
Grace A.H. Nguyen, Christopher Liang, Jogeshwar Mukherjee   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Noninvasive molecular imaging of neuroinflammation [PDF]

, 2011
Inflammation is a highly dynamic and complex adaptive process to preserve and restore tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous system (CNS) is now recognized to have a constant interplay with the innate and
Jacobs, A.H. (Andreas), Bertrand Tavitian, Windhorst, A.D., Lammertsma, A.A., Andreas H Jacobs, Jacobs, A.H., Jacobs, Andreas H., Tavitian, B. (Bertrand), INMiND consortium, Tavitian, Bertrand, Boutin, Herve; id_orcid, Planas, Anna M., Tavitian, B., et al., HENEKA, Michael, Jacobs, Andreas H   +15 more
core   +1 more source

Intratumoral in vivo staging of breast cancer by multi-tracer PET and advanced analysis

npj Breast Cancer, 2022
The staging and local management of breast cancer involves the evaluation of the extent and completeness of excision of both the invasive carcinoma component and also the intraductal component or ductal carcinoma in situ.
Jennifer Griessinger, Julian Schwab, Qian Chen, Anna Kühn, Jonathan Cotton, Gregory Bowden, Heike Preibsch, Gerald Reischl, Leticia Quintanilla-Martinez, Hidetoshi Mori, An Nguyen Dang, Ursula Kohlhofer, Olulanu H. Aina, Alexander D. Borowsky, Bernd J. Pichler, Robert D. Cardiff, Andreas M. Schmid   +16 more
doaj   +1 more source

Assessing the Functional Redundancy between P-gp and BCRP in Controlling the Brain Distribution and Biliary Excretion of Dual Substrates with PET Imaging in Mice

Pharmaceutics, 2021
P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are co-localized at the blood–brain barrier, where they display functional redundancy to restrict the brain distribution of dual P-gp/BCRP substrate drugs.
Irene Hernández-Lozano, Severin Mairinger, Alexander Traxl, Michael Sauberer, Thomas Filip, Johann Stanek, Claudia Kuntner, Thomas Wanek, Oliver Langer   +8 more
doaj   +1 more source