Results 31 to 40 of about 2,109,805 (291)
Why Preclinical Imaging and What Will Happen in the Future?
Frontiers in Biomedical Technologies, 2021 No ...
Razieh Solgi, Ehsan Sharif-Paghaleh
doaj +1 more source
Cells, 2022 Lewy bodies (LB) play a neuropathological role in Parkinson’s disease (PD). Our goal was to evaluate LB using anti-ubiquitin immunohistochemistry (UIHC) and find correlations with monoamine oxidase-A (MAO-A) using imaging agent, [18F]FAZIN3.
Jogeshwar Mukherjee +3 more
doaj +1 more source
Preclinical and Translational PET/MR Imaging [PDF]
Journal of Nuclear Medicine, 2014 Combined PET and MR imaging (PET/MR imaging) has progressed tremendously in recent years. The focus of current research has shifted from technologic challenges to the application of this new multimodal imaging technology in the areas of oncology, cardiology, neurology, and infectious diseases.
H. F. Wehrl +9 more
openaire +2 more sources
EJNMMI Research, 2022 Highlights In a focal rat DTH-EAE model of neuroinflammation, dimethyl fumarate decreases the uptake of TSPO PET tracer [18F]GE-180 in the short term. Long-term [18F]GE-180 follow-up did not indicate a treatment effect.
S. K. Vainio +10 more
doaj +1 more source
Molecules, 2023 Aggregation of Tau protein into paired helical filaments causing neurofibrillary tangles (NFT) is a neuropathological feature in Alzheimer’s disease (AD).
Roz R. Limpengco +3 more
doaj +1 more source
Near-Infrared Fluorescence Imaging in Preclinical Models of Glioblastoma
, 2023 Cancer is a public health problem requiring ongoing research to improve current treatments and discover novel therapies. More accurate imaging would facilitate such research.
Patricia Garcia-Lopez +3 more
core +1 more source
Semi-automated Image Processing for Preclinical Bioluminescent Imaging [PDF]
Journal of Applied Bioinformatics & Computational Biology, 2015 Bioluminescent imaging is a valuable noninvasive technique for investigating tumor dynamics and specific biological molecular events in living animals to better understand the effects of human disease in animal models. The purpose of this study was to develop and test a strategy behind automated methods for bioluminescence image processing from the ...
Nikolai V, Slavine, Roderick W, McColl
openaire +2 more sources
Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging. [PDF]
PLoS One, 2015 Bacterial nitroreductases (NTRs) have been widely utilized in the development of novel antibiotics, degradation of pollutants, and gene-directed enzyme prodrug therapy (GDEPT) of cancer that reached clinical trials. In case of GDEPT, since NTR is not naturally present in mammalian cells, the prodrug is activated selectively in NTR-transformed cancer ...
Vorobyeva AG +10 more
europepmc +10 more sources
Mouse models of neurodegenerative disease: preclinical imaging and neurovascular component. [PDF]
, 2017 Neurodegenerative diseases represent great challenges for basic science and clinical medicine because of their prevalence, pathologies, lack of mechanism-based treatments, and impacts on individuals.
S Albanese +7 more
core +2 more sources
Scientific Reports, 2021 Exposure to antibiotic treatment has been associated with increased vulnerability to various psychiatric disorders. However, a research gap exists in understanding how adolescent antibiotic therapy affects behavior and cognition.
Anouk C. Tengeler +7 more
doaj +1 more source