Results 31 to 40 of about 231,020 (192)
4th Internatinal TPCF Preclinical Imaging Symposium
Frontiers in Biomedical Technologies, 2021 Due to the huge costs and time spent for development of new drugs (around almost $ 1 billion (USD) and 12 Years), investing on the preclinical phase of drug development could be regarded as a great investment for de-risking the clinical phases ...
4th Internatinal TPCF Preclinical Imaging
doaj
Low-Dose Imaging in a New Preclinical Total-Body PET/CT Scanner
Frontiers in Medicine, 2019 Ionizing radiation constitutes a health risk to imaging scientists and study animals. Both PET and CT produce ionizing radiation. CT doses in pre-clinical in vivo imaging typically range from 50 to 1,000 mGy and biological effects in mice at this dose ...
Cesar Molinos +19 more
doaj +1 more source
Why Preclinical Imaging and What Will Happen in the Future?
Frontiers in Biomedical Technologies, 2021 No ...
Razieh Solgi, Ehsan Sharif-Paghaleh
doaj +1 more source
Lossy Image Compression in a Preclinical Multimodal Imaging Study
Journal of Digital Imaging, 2023 Abstract The growing use of multimodal high-resolution volumetric data in pre-clinical studies leads to challenges related to the management and handling of the large amount of these datasets. Contrarily to the clinical context, currently there are no standard guidelines to regulate the use of image compression in pre-clinical ...
Francisco Cunha +9 more
openaire +3 more sources
Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging. [PDF]
PLoS One, 2015 Bacterial nitroreductases (NTRs) have been widely utilized in the development of novel antibiotics, degradation of pollutants, and gene-directed enzyme prodrug therapy (GDEPT) of cancer that reached clinical trials. In case of GDEPT, since NTR is not naturally present in mammalian cells, the prodrug is activated selectively in NTR-transformed cancer ...
Vorobyeva AG +10 more
europepmc +8 more sources
Cells, 2022 Lewy bodies (LB) play a neuropathological role in Parkinson’s disease (PD). Our goal was to evaluate LB using anti-ubiquitin immunohistochemistry (UIHC) and find correlations with monoamine oxidase-A (MAO-A) using imaging agent, [18F]FAZIN3.
Jogeshwar Mukherjee +3 more
doaj +1 more source
Near-Infrared Fluorescence Imaging in Preclinical Models of Glioblastoma
, 2023 Cancer is a public health problem requiring ongoing research to improve current treatments and discover novel therapies. More accurate imaging would facilitate such research.
Patricia Garcia-Lopez +3 more
core +1 more source
Mouse models of neurodegenerative disease: preclinical imaging and neurovascular component. [PDF]
, 2017 Neurodegenerative diseases represent great challenges for basic science and clinical medicine because of their prevalence, pathologies, lack of mechanism-based treatments, and impacts on individuals.
S Albanese +7 more
core +2 more sources
EJNMMI Research, 2022 Highlights In a focal rat DTH-EAE model of neuroinflammation, dimethyl fumarate decreases the uptake of TSPO PET tracer [18F]GE-180 in the short term. Long-term [18F]GE-180 follow-up did not indicate a treatment effect.
S. K. Vainio +10 more
doaj +1 more source
Molecules, 2023 Aggregation of Tau protein into paired helical filaments causing neurofibrillary tangles (NFT) is a neuropathological feature in Alzheimer’s disease (AD).
Roz R. Limpengco +3 more
doaj +1 more source