Results 61 to 70 of about 231,020 (192)

[¹²⁵I]IPC-Lecanemab: Synthesis and Evaluation of Aβ-Plaque-Binding Antibody and Comparison with Small-Molecule [¹⁸F]Flotaza and [¹²⁵I]IBETA in Postmortem Human Alzheimer’s Disease

Neurology International
Therapeutic antibodies for reducing Aβ plaque load in Alzheimer’s disease (AD) is currently making rapid progress. The diagnostic imaging of Aβ plaque load in AD has been underway and is now used in clinical studies.
Christopher Liang, Cayz G. Paclibar, Noresa L. Gonzaga, Stephanie A. Sison, Harman S. Bath, Agnes P. Biju, Jogeshwar Mukherjee   +6 more
doaj   +1 more source

Advances in molecular preclinical therapy mediated by imaging.

, 2017
Several advances have been made toward understanding the biology of cancer and most of them are due to robust genetic studies that led to the scientific recognition that although many patients have the same type of cancer their tumors may have harbored ...
Salvatore M., DE Carlo F, Howard CM, Salvatore M, Albanese S, Auletta L., De Carlo F., Claudio PP, Albanese S., GRECO, ADELAIDE, Claudio P. P., Auletta L, Greco A., Howard C. M.   +13 more
core   +1 more source

Standardization of Preclinical PET/CT Imaging to Improve Quantitative Accuracy, Precision, and Reproducibility:A Multicenter Study [PDF]

, 2019
Preclinical PET/CT is a well-established noninvasive imaging tool for studying disease development/progression and the development of novel radiotracers and pharmaceuticals for clinical applications.
Welch, A, Mingarelli, M, Schneider, JE, Tavares, Adriana A. S., Vanhove, C, Lewellen, B, Corral, Carlos Alcaide, Tavares, Adriana, Newby, David, Mcdougald, Wendy, Vandenberghe, S, Mingarelli, Marco, Lehnert, Adrienne, Tavares, AAS, Corral, Carlos, Welch, Andy, Schneider, Jurgen, McDougald, W, Newby, DE, Wright, John, Plein, S, Lewellen, Barbara, Miyaoka, Robert, Schneider, Jurgen E., Tavares, Adriana Alexandre S., Lehnert, A, Miyaoka, R, Corral, CA, Plein, Sven, Vandenberghe, Stefaan, Wright, J, Vanhove, Christian   +31 more
core   +1 more source

Evaluation of [¹²⁵I]α-Bungarotoxin Binding to α7 Nicotinic Acetylcholinergic Receptors in Hippocampus–Subiculum of Postmortem Human Alzheimer’s Disease Brain

Receptors
Background/Objectives: Alzheimer’s disease (AD) severely hinders cognitive function in the hippocampus (HP) and subiculum (SUB), impacting the expression of nicotinic acetylcholine receptors (nAChRs) such as the α7-subtype.
Allyson Ngo, Fariha Karim, Oshini V. Keerthisinghe, Tram B. Danh, Christopher Liang, Jogeshwar Mukherjee   +5 more
doaj   +1 more source

Non-invasive molecular imaging for preclinical cancer therapeutic development. [PDF]

, 2013
Molecular and non-invasive imaging are rapidly emerging fields in preclinical cancer drug discovery. This is driven by the need to develop more efficacious and safer treatments, the advent of molecular targeted therapeutics, and the requirements to ...
Shnyder, SD, Colletta, L, Gill, JH, O'Farrell, AC, Marston, Gemma, Marston, G   +5 more
core   +1 more source

Whole-Body Photoacoustic Imaging Techniques for Preclinical Small Animal Studies

, 2022
Photoacoustic imaging is a hybrid imaging technique that has received considerable attention in biomedical studies. In contrast to pure optical imaging techniques, photoacoustic imaging enables the visualization of optical absorption properties at deeper
Kim, Chulhong, Song, Yuon, Hyunjun Kye, Jeesu Kim, Kye, Hyunjun, Kim, Jeesu, Tsedendamba Ninjbadgar, Yuon Song, Ninjbadgar, Tsedendamba, Chulhong Kim   +9 more
core   +1 more source

Preclinical Open-Sided Magnetic Particle Imaging Scanner

Preclinical magnetic particle imaging (MPI) plays a crucial role in advancing biomedical research through in vivo studies and helps with the translation into clinical systems.
Yazar Buran, Şirin, Karaca, Sefa, Alptekin Soydan, Damla, Top, Can Barış, Özaslan, Ali Alper   +4 more
core   +1 more source

Amyloid tracers detect multple binding sites in Alzheimer´s disease brain tissue. [PDF]

, 2013
Imaging fibrillar amyloid-β deposition in the human brain in vivo by positron emission tomography has improved our understanding of the time course of amyloid-β pathology in Alzheimer’s disease. The most widely used amyloid-β imaging tracer so far is 11C-
Nordberg, A,, Ni, Ruiqing, Marutle, Amelia, Gillberg, P-G, Marutle, A,, Bergfors, A, Nordberg, Agneta, Gillberg, Per-Göran, Bergfors, Assar, Ni, R,   +9 more
core   +1 more source

Assessing PET performance, image quality, and attenuation correction in the presence of RF coils within a 9.4 T MRI for preclinical simultaneous imaging

EJNMMI Physics
Background This study evaluates the performance of a positron emission tomography (PET) insert combined with a 9.4 Tesla magnetic resonance (MR) imaging system using three different radiofrequency (RF) coils.
Claudia Kuntner, Joachim Friske, Andrea Stessl, Martin Haas, Lara Luna Breyer, Thomas Wanek, Marcus Hacker, Thomas Helbich, Ivo Rausch   +8 more
doaj   +1 more source

Assessment of [¹²⁵I]a-Bungarotoxin Binding to a7 Nicotinic Acetylcholinergic Receptors in Hippocampus-Subiculum of Postmortem Human Parkinson’s Disease Brain

Biomolecules
Parkinson’s disease (PD) involves motor and cognitive impairment that nicotinic acetylcholine receptors (nAChRs) such as the α7 subtype are responsible for regulating.
Fariha Karim, Allyson Ngo, Titus E. Tucker, Ashlee D. L. Coronel, Jogeshwar Mukherjee   +4 more
doaj   +1 more source