Results 141 to 150 of about 507,231 (378)

Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden, Charles Carron, Donatienne Van Weehaeghe, Joke De Vocht, Fouke Ombelet, Pegah Masrori, Caro De Weerdt, Rebecca E. James, Lauren T. Evans, Frederick A. Schroeder, Jacob M. Hooker, Michel Koole, Janice E. Kranz, Tonya M. Gilbert, Philip Van Damme, Koen Van Laere   +15 more
wiley   +1 more source

Community Survey Results Show that Standardisation of Preclinical Imaging Techniques Remains a Challenge. [PDF]

Mol Imaging Biol, 2023
Tavares AAS, Mezzanotte L, McDougald W, Bernsen MR, Vanhove C, Aswendt M, Ielacqua GD, Gremse F, Moran CM, Warnock G, Kuntner C, Huisman MC.   +11 more
europepmc   +1 more source

A Preclinical Large Animal Model of Adenovirus-Mediated Expression of the Sodium–Iodide Symporter for Radioiodide Imaging and Therapy of Locally Recurrent Prostate Cancer [PDF]

, 2005
Róisín M. Dwyer, Stephen M. Schatz, Elizabeth R. Bergert, Rae Myers, Mary Harvey, Kelly Classic, Michael C. Blanco, Craig S. Frisk, Ronald J. Marler, Brian J. Davis, Michael K. O’Connor, Stephen J. Russell, John C. Morris   +12 more
openalex   +1 more source

3D Wasserstein generative adversarial network with dense U-Net based discriminator for preclinical fMRI denoising [PDF]

arXiv
Functional magnetic resonance imaging (fMRI) is extensively used in clinical and preclinical settings to study brain function, however, fMRI data is inherently noisy due to physiological processes, hardware, and external noise. Denoising is one of the main preprocessing steps in any fMRI analysis pipeline.
arxiv  

Myostatin Levels in SMA Following Disease‐Modifying Treatments: A Multi‐Center Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study investigated myostatin levels in SMA patients receiving disease‐modifying therapies (DMTs) to understand their relationship with treatment duration and functional status. Methods Our study includes both cross‐sectional and longitudinal analyses of myostatin levels in treated SMA patients.
Fiorella Piemonte, Sara Petrillo, Anna Capasso, Giorgia Coratti, Adele D'Amico, Michela Catteruccia, Maria Carmela Pera, Concetta Palermo, Marika Pane, Emanuela Abiusi, Gianpaolo Cicala, Marianna Villa, Chiara Bravetti, Chiara Arpaia, Agnese Novelli, Salvatore Falqui, Stefania Fiori, Giulia Napoli, Silvia Baroni, Francesco Danilo Tiziano, Enrico Bertini, Giacomo Comi, Stefania Corti, Eugenio Mercuri   +23 more
wiley   +1 more source

Co-Clinical Imaging Metadata Information (CIMI) for Cancer Research to Promote Open Science, Standardization, and Reproducibility in Preclinical Imaging. [PDF]

Tomography, 2023
Moore SM, Quirk JD, Lassiter AW, Laforest R, Ayers GD, Badea CT, Fedorov AY, Kinahan PE, Holbrook M, Larson PEZ, Sriram R, Chenevert TL, Malyarenko D, Kurhanewicz J, Houghton AM, Ross BD, Pickup S, Gee JC, Zhou R, Gammon ST, Manning HC, Roudi R, Daldrup-Link HE, Lewis MT, Rubin DL, Yankeelov TE, Shoghi KI.   +26 more
europepmc   +1 more source

418 Relationship between preclinical abnormalities of global and regional left ventricular function and insulin resistance in severe obesity: a color Doppler imaging study [PDF]

, 2005
Vitantonio Di Bello, Ferruccio Santini, Andrea Di Cori, Angela Pucci, Caterina Palagi, Maria Grazia Delle Donne, Enrica Talini, Alberto Balbarini   +7 more
openalex   +1 more source

A Novel Metamaterial-Inspired RF-coil for Preclinical Dual-Nuclei MRI [PDF]

arXiv, 2017
In this paper we propose, design and test a new dual-nuclei RF-coil inspired by wire metamaterial structures. The coil operates due to resonant excitation of hybridized eigenmodes in multimode flat periodic structures comprising several coupled thin metal strips. It was shown that the field distribution of the coil (i.e.
arxiv  

Editorial: Status Go for Preclinical Imaging [PDF]

Frontiers in Physics, 2020
Kuntner, Claudia, Baumann, Bernhard, Tavares, Adriana A S, Hess, Andreas   +3 more
openaire   +5 more sources

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source