Results 141 to 150 of about 6,725,081 (364)

Figure S1 from Preclinical Development and First-in-Human Imaging of the Integrin α_vβ₆ with [¹⁸F]α_vβ₆-Binding Peptide in Metastatic Carcinoma

, 2023
Sven H. Hausner, Richard J. Bold, Lina Y. Cheuy, Helen K. Chew, Megan E. Daly, Ryan A. Davis, Cameron C. Foster, Edward Kim, Julie L. Sutcliffe   +8 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Mapping serotonergic dynamics using drug-modulated molecular connectivity in rats

eLife
Understanding the complex workings of the brain is one of the most significant challenges in neuroscience, providing insights into normal brain function, neurological diseases, and the effects of potential therapeutics.
Tudor M Ionescu, Mario Amend, Rakibul Hafiz, Andreas Maurer, Bharat Biswal, Hans F Wehrl, Kristina Herfert   +6 more
doaj   +1 more source

Development and Successful Validation of Simple and Fast TLC Spot Tests for Determination of Kryptofix® 2.2.2 and Tetrabutylammonium in 18F-Labeled Radiopharmaceuticals

Pharmaceuticals, 2014
Kryptofix® 2.2.2 (Kry) or tetrabutylammonium (TBA) are commonly used as phase transfer catalysts in 18F-radiopharmaceutical productions for positron emission tomography (PET).
Matthias Kuntzsch, Denis Lamparter, Nils Brüggener, Marco Müller, Gabriele J. Kienzle, Gerald Reischl   +5 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Early diagnosis of Alzheimer's disease: update on combining genetic and brain-imaging measures. [PDF]

, 2000
Diagnosis of Alzheimer's disease is often missed or delayed in clinical practice; thus, methods to improve early detection would provide opportunities for early intervention, symptomatic treatment, and improved patient function.
Small, GW
core   +1 more source

Comparative effectiveness and safety of image guidance systems in neurosurgery: a preclinical randomized study [PDF]

, 2015
Hani J. Marcus, Philip Pratt, Archie Hughes‐Hallett, Thomas P. Cundy, Adam Marcus, Guang‐Zhong Yang, Ara Darzi, Dipankar Nandi   +7 more
openalex   +1 more source

An AI Dietitian for Type 2 Diabetes Mellitus Management Based on Large Language and Image Recognition Models: Preclinical Concept Validation Study (Preprint)

, 2023
Haonan Sun, Kai Zhang, Wei Lan, Q. Gu, Guangxiang Jiang, Xue Yang, Wanli Qin, Dongran Han   +7 more
openalex   +1 more source

Development and preclinical evaluation of [68Ga]Ga-Alb-FAPtp-01, a novel tumour-associated fibroblast activation protein tracer for PET imaging of xenograft glioma [PDF]

, 2021
Jiajia Lin, Chia-Pao Chuang, Jiayu Lin, Feng‐Ting Huang, Chiun‐Wei Huang   +4 more
openalex   +1 more source