Results 151 to 160 of about 2,109,805 (291)

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Why the preclinical imaging field needs nuclear medicine technologists and radiographers? [PDF]

Eur J Hybrid Imaging, 2020
Dillenseger JP, Choquet P, Snay ER, Fragoso Costa P.   +3 more
europepmc   +1 more source

XTRUDE: A Process‐Informed Framework for High‐Fidelity Analysis of Hydrogel Extrusion

Advanced Functional Materials, EarlyView.
Extrusion performance emerges from the interplay between material properties and processing conditions. XTRUDE (eXTrusion Rheology for Understanding and Defining Extrudability) recreates the extrusion environment with in situ pressure and temperature sensing, enabling characteristic pressure signatures to quantify extrusion‐specific phenomena and ...
Farhad Sanaei, Pascal Bertsch, Juliette Lafosse, Sander C. G. Leeuwenburgh, Mani Diba   +4 more
wiley   +1 more source

Developing a system for the molecular imaging of freely moving rats

, 2012
Using molecular imaging to obtain time-activity data from the organs of living animals that are free to move, behave and respond to stimuli is a tantalising prospect for preclinical investigations.
Ryder, Will., Meikle, Steven R., Kyme, Andre Z., Fulton, Roger R., R Bashir (9897038), Angelis, Georgios., K Popovic (9895133), Bashir, Rezaul., R Fulton (9890711), W Ryder (9897032), S Meikle (9890720), Zhou, Victor., A Kyme (9890708), Eisenhuth, John., Popovic, Kata., G Angelis (9897035), J Eisenhuth (9893696), Weidong Zhou (9847925)   +17 more
core  

Protocols for Dual Tracer PET/SPECT Preclinical Imaging. [PDF]

Front Phys, 2020
Blower JE, Bordoloi JK, Rigby A, Farleigh M, Kim J, O'Brien H, Jackson J, Poyiatzis C, Bezer J, Sunassee K, Blower PJ, Livieratos L.   +11 more
europepmc   +1 more source

Prostate Cancer Patient‐Derived Organoids (PDOs) as Functional Avatars for Antisense Oligonucleotide (ASO)‐Based Personalized Therapy

Advanced Healthcare Materials, EarlyView.
Prostate patient‐derived organoids (PDOs) were established from TURP and biopsy specimens with >90% success and retain key features of their tissues of origin, making them functional avatars for antisense oligonucleotide (ASO) therapy . Transfecting single cells outside the Matrigel matrix and then reconstituting organoids overcomes the 3D delivery ...
Thi Thom Tran, Thi Tu Uyen Phan, Michael Baboudjian, Quang Hieu Duong, Ines Sousa, Thi Thuy Le, Virginie Baylot, Sophie Giusiano, Laurent Daniel, Pauline Brige, Benjamin Guillet, Cyrille Bastide, Carmen Garrido, David Taïeb, Thi Khanh Le, Palma Rocchi   +15 more
wiley   +1 more source

A Fluorescent Probe as a Lead Compound for a Selective α‑Synuclein PET Tracer: Development of a Library of 2‑Styrylbenzothiazoles and Biological Evaluation of [18F]PFSB and [18F]MFSB

ACS Omega, 2023
Adriana Di Nanni, Ran Sing Saw, Umberto M. Battisti, Gregory D. Bowden, Adam Boeckermann, Kaare Bjerregaard-Andersen, Bernd J. Pichler, Kristina Herfert, Matthias M. Herth, Andreas Maurer   +9 more
doaj   +1 more source

Tomographic Ultrasound and LED-Based Photoacoustic System for Preclinical Imaging. [PDF]

Sensors (Basel), 2020
Francis KJ, Booijink R, Bansal R, Steenbergen W.   +3 more
europepmc   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source