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Clinical and Preclinical Imaging of Hepatosplenic Schistosomiasis [PDF]
Schistosomiasis, a neglected tropical disease, is a major cause of chronic morbidity and disability, and premature death. The hepatosplenic form of schistosomiasis is characterized by hepatosplenomegaly, liver fibrosis, portal hypertension, and esophageal varices, whose rupture may cause bleeding and death.
Teodora-Adriana Perles-Barbacaru +1 more
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Biomarkers in preclinical cancer imaging [PDF]
In view of the trend towards personalized treatment strategies for (cancer) patients, there is an increasing need to noninvasively determine individual patient characteristics. Such information enables physicians to administer to patients accurate therapy with appropriate timing.
Monique R Bernsen +2 more
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Preclinical Imaging of Cardiovascular Disesase
Seminars in Nuclear Medicine, 2023Noninvasive imaging techniques, such as SPECT, PET, CT, echocardiography, or MRI, have become essential in cardiovascular research. They allow for the evaluation of biological processes in vivo without the need for invasive procedures. Nuclear imaging methods, such as SPECT and PET, offer numerous advantages, including high sensitivity, reliable ...
Stephan G. Nekolla +2 more
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Imaging Functional Recovery Following Ischemic Stroke: Clinical and Preclinical fMRI Studies
Disability and effectiveness of physical therapy are highly variable following ischemic stroke due to different brain regions being affected. Functional magnetic resonance imaging (fMRI) studies of patients in the months and years following stroke have ...
Michael E Kelly, Claire L Gibson
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Challenges in Imaging in Preclinical Rheumatoid Arthritis
Rheumatic Disease Clinics of North America, 2014There exists a preclinical phase to the disease progression of rheumatoid arthritis, in which there is evidence of autoimmunity but no overt clinical arthritis. Identifying patients in this phase would allow for early treatment, to potentially halt manifestation of the disease.
Lisa A Mandl
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Technologies: preclinical imaging for drug development
Drug Discovery Today: Technologies, 2013Preclinical imaging with magnetic resonance imaging (MRI), computerised tomography (CT), ultrasound (US), positron emission tomography (PET) or single-photon emission computed tomography (SPECT) enable non-invasive measures of tissue structure, function or metabolism in vivo.
Paul M, Matthews +6 more
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Ethics of Preclinical Dopamine Transporter Imaging
Continuum, 2016While dopamine transporter single-photon emission computed tomography (DAT-SPECT) imaging is sensitive and specific when performed in patients with signs or symptoms of parkinsonism, its predictive value is uncertain in healthy subjects, even with patients who have first-degree relatives affected by Parkinson disease.
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Preclinical MRI Experience in Imaging Angiogenesis
Cancer and Metastasis Reviews, 2000Magnetic resonance imaging (MRI) provides a range of non-invasive measures for visualization of tumor angiogenesis in the clinic as well as in experimental tumor models. MRI methods were developed for assessment of spatial and temporal changes in perfusion, blood volume fraction, vascular permeability, vascular function, vascular maturation, vessel ...
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Preclinical Imaging for Laboratory Rodents
2021Laboratory animals play an important role in biomedical research and act as a backbone of new drug research and development. Biomedical research is primarily dependent on laboratory rodents. There is a steady shift of therapeutic strategies for diseases from physiological to cellular and presently molecular targets.
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Imaging in Clinical and Preclinical Practice
2017Over the years, medical imaging has become an inherent part of modern medicine and biomedical engineering. Various imaging methods, which provide the detailed insight into human body interior, are widely used in clinical and preclinical practice. They enable the accurate diagnosis of complex pathological states, planning and performing of challenging ...
Sladjana Petrović, Nikola Korunović
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