Results 161 to 170 of about 114,558 (301)

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

Advanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Melissa A. Willman, Alexander Rabassa, Ashley L. Joubert, Tommaso Bo, Letizia Franco, Marzia Conte, Ana L. Anaya‐García, Gabrielle E. Rome, Rim Ouni, Henry J. Seaborne, Camden A. Caffey, Dora M. Berman, Junjun Zheng, Jesus Paez‐Mayorga, Corrine Ying Xuan Chua, Shu Hsia Chen, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Preclinical pharmacokinetics, interspecies scaling, and pharmacokinetics of a Phase I clinical trial of TTAC-0001, a fully human monoclonal antibody against vascular endothelial growth factor 2

Drug Design, Development and Therapy, 2018
Weon Sup Lee,1 Sang Ryeol Shim,1 Seon Young Lee,1 Jin San Yoo,1 Sung Kweon Cho2 1PharmAbcine, Inc., Daejeon, Republic of Korea; 2Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea Background: VEGF is
Lee WS, Shim SR, Lee SY, Yoo JS, Cho SK
doaj  

Population‐Based Modeling to Predict Human PK/PD of TAK‐500, an Anti‐CCR2 Antibody–Drug Conjugate for First‐in‐Human Study in Cancer Patients

Clinical and Translational Science
TAK‐500 is a novel immune cell–directed antibody–drug conjugate (iADC) composed of TAK‐202, an anti‐CCR2 monoclonal antibody, conjugated to the STING agonist dazostinag (TAK‐676), and is designed to stimulate antitumor immunity by reprogramming CCR2 ...
Anitha Saravanakumar, Rong Deng, Linlin Dong, Satyajeet Haridas, Cindy Q. Xia, Vicky A. Appleman, Adnan O. Abu‐Yousif, Konstantin Piatkov, Haiqing Wang   +8 more
doaj   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Ligand non-competitive GITR antibody prevents formation of the obligatory signal-triggering GITRL: GITR stoichiometry

Scientific Reports
The prevalence of autoimmune diseases such as inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) is increasing. Glucocorticoid-induced TNFR-related protein (GITR), a TNF receptor superfamily (TNFRSF) member, is activated by GITR-ligand (GITRL)
Jing Yan, Jessica Min-DeBartolo, Ching-Shin Huang, M. Nusrat Sharif, Li Li, Susan Fish, Corey Dower, Denise Murphy, Tatyana Andreyeva, Heng Liu, Xinbing Han, Wei Zheng, Jot Hui Ooi, Jason Edmonds, Ting Chen, Zachary Maben, Chad R. Stevens, Polina Goihberg, Malgorzata Nocula-Lugowska, Steven M Evans, Lidia Mosyak, Kerry Kelleher, Caitlyn Dickinson, Martin Hegen, Aaron Winkler, Fridrik Karlsson   +25 more
doaj   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Preclinical Pharmacokinetics and Acute Toxicity in Rats of 5-{[(2E)-3-Bromo-3-carboxyprop-2-enoyl]amino}-2-hydroxybenzoic Acid: A Novel 5-Aminosalicylic Acid Derivative with Potent Anti-Inflammatory Activity. [PDF]

Molecules, 2021
Gutiérrez-Sánchez M, Romero-Castro A, Correa-Basurto J, Rosales-Hernández MC, Padilla-Martínez II, Mendieta-Wejebe JE.   +5 more
europepmc   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source