Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs. [PDF]
PLoS ONE, 2020 Intranasal ketamine has recently gained interest in human medicine, not only for its sedative, anaesthetic or analgesic properties, but also in the management of treatment resistant depression, where it has been shown to be an effective, fast acting ...
Lise Vlerick +6 more
doaj +4 more sources
Safety, Pharmacokinetics/Pharmacodynamics, and Absolute Bioavailability of Dexmedetomidine Hydrochloride Nasal Spray in Healthy Subjects: A Randomized, Parallel, Escalating Dose Study [PDF]
Frontiers in Pharmacology, 2022 Background: The present study evaluated the safety, pharmacokinetics/pharmacodynamics (PK/PD), and absolute bioavailability (Fabs) of Dex nasal spray in healthy adult subjects, which serves as a bridge for the subsequent study in children.Methods: Part 1:
Yun Kuang +17 more
doaj +2 more sources
The Pharmacokinetic and Absolute Bioavailability of Cyclosporine (Atopica for Cats®) in Cats [PDF]
Veterinary Sciences, 2023 This study aimed to evaluate the absolute bioavailability of cyclosporine in cats by investigating the pharmacokinetic profile after intravenous and oral administration, respectively.
Jingyuan Kong +6 more
doaj +2 more sources
Rilzabrutinib, a reversible covalent Bruton's tyrosine kinase inhibitor: Absorption, metabolism, excretion, and absolute bioavailability in healthy participants [PDF]
Clinical and Translational Science, 2023 This single‐center, open‐label, non‐randomized, two‐part, phase I study was conducted (1) to evaluate the absolute oral bioavailability of rilzabrutinib 400 mg tablet following an i.v.
Sibel Ucpinar +9 more
doaj +2 more sources
Pharmacokinetics of Lekethromycin in Swine Following Intramuscular Administration at Different Doses with a Single Intravenous Reference Dose for Absolute Bioavailability and Matrix Comparison [PDF]
Veterinary SciencesLekethromycin (LKMS) is a novel macrolide veterinary antimicrobial. Its propensity for intracellular accumulation causes discrepancies between whole blood and plasma concentrations, complicating pharmacokinetic evaluations.
Qinyao Wu +7 more
doaj +2 more sources
Absolute Bioavailability, Tissue Distribution, and Excretion of Erinacine S in Hericium erinaceus Mycelia [PDF]
Molecules, 2019 Erinacine S, so far known to have been produced only in Hericium erinaceus mycelia, has just recently been discovered and is able to reduce amyloid plaque growth and improve neurogenesis in aged brain of rats.
Jun-Hao Hu +6 more
doaj +2 more sources
Open‐Label Study Assessing Relative and Absolute Bioavailability of Oral Camizestrant Formulations and Food Effects in Healthy Postmenopausal Women [PDF]
Clinical and Translational ScienceCamizestrant is the next‐generation oral selective estrogen receptor degrader and complete estrogen receptor antagonist in Phase 3 development for hormone receptor‐positive breast cancer.
Andy Sykes +15 more
doaj +2 more sources
Modifications of the Method for Calculating Absolute Drug Bioavailability
Journal of Pharmacy & Pharmaceutical Sciences, 2016 Purpose: Absolute bioavailability (F) is calculated as the ratio of the area under the plasma drug concentration-time curve (AUC) between extravascular administration and intravenous injection.
Wei Jiang +5 more
doaj +4 more sources
Effect of anions or foods on absolute bioavailability of calcium from calcium salts in mice by pharmacokinetics [PDF]
Journal of Experimental Pharmacology, 2013 Yukari Ueda, Zenei TairaFaculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, JapanAbstract: We studied the absolute bioavailability of calcium from calcium L-lactate in mice using pharmacokinetics, and reviewed the absolute ...
Ueda Y, Taira Z
doaj +2 more sources
The stable isotope method for determining absolute bioavailability. [PDF]
Transl Clin Pharmacol, 2017 The bioavailability of a drug is usually assessed in healthy subjects. However, it is reasonable to expect that significant alterations in bioavailability may occur in actual patients with different diseases or in individuals belonging to special populations. Relatively few studies have been conducted to examine this possibility.
Atkinson AJ.
europepmc +3 more sources