Results 11 to 20 of about 95,952 (294)

Characterization of the Pharmacokinetics of Samidorphan in Healthy Volunteers: Absolute Bioavailability and the Effect of Food and Age [PDF]

Drugs in R&D, 2019
Background and Objectives Samidorphan (SAM) is a novel μ-opioid receptor antagonist. We report clinical pharmacokinetic (PK) properties of SAM following different routes of administration, and the effects of food and age on the PK of SAM following oral ...
Vipul Kumar, Hong Lu, Marjie Hard, Lisa von Moltke   +3 more
doaj   +2 more sources

Non-linear pharmacokinetics of penciclovir in healthy cats after single and multiple oral administration of famciclovir [PDF]

Frontiers in Veterinary Science
IntroductionFeline Infectious Rhinobronchitis (FVR) is a common and serious infectious upper respiratory disease. Famciclovir, an antiviral prodrug initially developed for human herpesviruses, demonstrates significant therapeutic efficacy in cats with ...
Mengke Qu, Xiao Ke, Zhirong Zhang, Ling Zhang   +3 more
doaj   +2 more sources

Pilot toxicokinetic study and absolute oral bioavailability of the Fusarium mycotoxin enniatin B1 in pigs [PDF]

Food and Chemical Toxicology, 2014
Mathias Devreese, Sophie Fraeyman, Siska Croubels   +2 more
exaly   +3 more sources

A microdosing framework for absolute bioavailability assessment of poorly soluble drugs: A case study on cold‐labeled venetoclax, from chemistry to the clinic [PDF]

Clinical and Translational Science, 2022
Rajeev Menon, Ahmed Hamed Salem
exaly   +2 more sources

Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in rats. Part 1. Single and multiple intravascular and extravascular administration. Testing the hypothesis of linearity of pharmacokinetics

Фармакокинетика и Фармакодинамика, 2023
The pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in the rat blood plasma after different routes of administration was studied. The drug was administered at dose of 150 mg/kg by single and repeatedly.
O. Yu. Kravtsova, O. G. Gribakina, G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, P. Yu. Povarnina, V. P. Zherdev   +6 more
doaj   +1 more source

Absolute bioavailability of a substance with cardioprotective activity (ALM-802) in rats

Фармакокинетика и Фармакодинамика, 2022
The pharmacokinetics of a new potential cardioprotective agent ALM-802 was studied in rats after single intravenous and intragastric administration at doses of 10 and 100 mg/kg, respectively.
G. B. Kolyvanov, P. O. Bochkov, A. A. Litvin, R. V. Shevchenko, A. L. Podolko, V. P. Zherdev   +5 more
doaj   +1 more source

Absolute bioavailability and regional absorption of ticagrelor in healthy volunteers [PDF]

Journal of Drug Assessment, 2014
Teng R, Maya J.
exaly   +2 more sources

Prolonged low flow reduces reactive hyperemia and augments low flow mediated constriction in the brachial artery independent of the menstrual cycle [PDF]

, 2013
© 2013 Rakobowchuk et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
AE Devan, AM Malek, B Jiang, CM Pedersen, DHJ Thijssen, Emily R. Parsloe, Emma Harris, GP Fadini, J Pleiner, Karen M. Birch, KE Pyke, LE Spieker, M Rakobowchuk, Mark Rakobowchuk, MI Okorie, MW Broadhead, Nick Ashton, RA Harris, RK Kharbanda, Sarah E. Gibbins, SP Loukogeorgakis, SP Loukogeorgakis, SP Loukogeorgakis, T Gori, T Gori, T Gori, T Gori, TL Weissgerber   +27 more
core   +7 more sources

Short‐ and long‐term effects of body weight loss following calorie restriction and gastric bypass on CYP3A‐activity – a non‐randomized three‐armed controlled trial

Clinical and Translational Science, 2022
It remains uncertain whether pharmacokinetic changes following Roux‐en‐Y gastric bypass (RYGB) can be attributed to surgery‐induced gastrointestinal alterations per se and/or the subsequent weight loss. The aim was to compare short‐ and long‐term effects
Kine Eide Kvitne, Ida Robertsen, Eva Skovlund, Hege Christensen, Veronica Krogstad, Christine Wegler, Philip Carlo Angeles, Birgit Malene Wollmann, Kristine Hole, Line Kristin Johnson, Rune Sandbu, Per Artursson, Cecilia Karlsson, Shalini Andersson, Tommy B. Andersson, Jøran Hjelmesæth, Rasmus Jansson‐Löfmark, Anders Åsberg   +17 more
doaj   +1 more source

Absolute oral bioavailability of ciprofloxacin [PDF]

Antimicrobial Agents and Chemotherapy, 1986
We evaluated the absolute bioavailability of ciprofloxacin, a new quinoline carboxylic acid, in 12 healthy male volunteers. Doses of 200 mg were given to each of the volunteers in a randomized, crossover manner 1 week apart orally and as a 10-min intravenous infusion.
G L, Drusano, H C, Standiford, K, Plaisance, A, Forrest, J, Leslie, J, Caldwell   +5 more
openaire   +2 more sources