Results 21 to 30 of about 95,952 (294)

Prediction of absolute bioavailability of medicines in children: based on predicted pediatric clearance from adults [PDF]

Exploration of Drug Science
Aim: The objective of this study was to evaluate the predictive performance of a proposed method to predict absolute bioavailability of medicines in children (infants to adolescents).
Iftekhar Mahmood
doaj   +1 more source

Metabolic profile, bioavailability and toxicokinetics of zearalenone-14-glucoside in rats after oral and intravenous administration by liquid chromatography high-resolution mass spectrometry and tandem mass spectrometry [PDF]

, 2019
Zearalenone-14-glucoside (ZEN-14G), a key modified mycotoxin, has attracted a great deal of attention due to the possible conversion to its free form of zearalenone (ZEN) exerting toxicity.
De Boevre, Marthe, De Saeger, Sarah, Li, Yanshen, Li, Yi, Rao, Zhenghua, Sun, Feifei, Tan, Haiguang, Yang, Shupeng, Zhang, Huiyan, Zhou, Jinhui   +9 more
core   +1 more source

Quantitative determination of D4-cystine in mice using LC-MS/MS and its application to the assessment of pharmacokinetics and bioavailability

Journal of Pharmaceutical Analysis, 2021
Cystine is the primary source material for the synthesis of glutathione. However, the pharmacokinetics and tissue distribution of cystine are largely unknown.
Shuning Li, Zhenyao Lu, Li Jiao, Ran Zhang, Yu Hong, Jiye Aa, Guangji Wang   +6 more
doaj   +1 more source

Pharmacokinetics of dipeptide mimetic BDNF GSB-106 in rats

Фармакокинетика и Фармакодинамика, 2019
Pharmacokinetics of the GSB-106 in variety of administration ways in rats was studied. After single oral administration the test substance was determined for 4 h in the blood plasma. Half-life was 0.65 h.
V. P. Zherdev, G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, O. G. Gribakina, R. V. Shevchenko, A. V. Tarasyuk, T. A. Gudasheva   +7 more
doaj   +1 more source

Pharmacokinetics of niazirin from Moringa oleifera Lam in rats by UPLC‐MS/MS: Absolute bioavailability and dose proportionality

eFood, 2022
Niazirin is a nitrile glycoside isolated from the pods and leaves of Moringa oleifera and possesses antidiabetic activity. However, its pharmacokinetic properties have not been well studied yet.
Fang Wang, Gaohong Yang, Yang Zhou, Haizhong Song, Ling Xiong, Luanfeng Wang, Xinchun Shen   +6 more
doaj   +1 more source

Rectal Bioavailability of Amoxicillin from Hollow-Type Suppositories: Effect of Chemical Form of Amoxicillin

Pharmaceutics, 2023
Rectal drug administration could offer advantages in the delivery of medicines for children by avoiding swallowability issues, improving stability and enabling administration by caregivers.
Trusha J. Purohit, Satya Amirapu, Zimei Wu, Sara M. Hanning   +3 more
doaj   +1 more source

Linear cyclodextrin polymer prodrugs as novel yherapeutics for Niemann-Pick type C1 disorder [PDF]

, 2018
Niemann-Pick Type C1 disorder (NPC) is a rare lysosomal storage disease characterized by the accumulation of cholesterol in lysosomes. NPC has no FDA approved treatments yet, however 2-hydroxypropyl-β-cyclodextrin (HPβCD) has shown efficacy for treating ...
Aditya Kulkarni, Alberto Macone, Atul Dolas, Jessica Dragotto, Maria Teresa Fiorenza, Paola Caporali, Ramesh Jayaraman, Sandeep Goyal, Soniya Johny   +8 more
core   +1 more source

Comparable Bioavailability and Disposition of Pefloxacin in Patients with Cystic Fibrosis and Healthy Volunteers Assessed via Population Pharmacokinetics

Pharmaceutics, 2019
Quinolone antibiotics present an attractive oral treatment option in patients with cystic fibrosis (CF). Prior studies have reported comparable clearances and volumes of distribution in patients with CF and healthy volunteers for primarily renally ...
Jürgen B. Bulitta, Yuanyuan Jiao, Cornelia B. Landersdorfer, Dhruvitkumar S. Sutaria, Xun Tao, Eunjeong Shin, Rainer Höhl, Ulrike Holzgrabe, Ulrich Stephan, Fritz Sörgel   +9 more
doaj   +1 more source

Hepcidin and iron homeostasis during pregnancy. [PDF]

, 2014
Hepcidin is the master regulator of systemic iron bioavailability in humans. This review examines primary research articles that assessed hepcidin during pregnancy and postpartum and report its relationship to maternal and infant iron status and birth ...
Cadwell, Brooke, Day, Jessica, Koenig, Mary Dawn, Nemeth, Elizabeta, Tussing-Humphreys, Lisa   +4 more
core   +1 more source

Agomelatine-based in situ gels for brain targeting via the nasal route: statistical optimization, in vitro, and in vivo evaluation

Drug Delivery, 2017
Agomelatine (AGM) is an antidepressant drug with a low absolute bioavailability due to the hepatic first pass metabolism. AGM-loaded solid lipid nanoparticles were formulated in the form of an in situ gel to prolong the intranasal retention time and ...
Ahmed M. Fatouh, Ahmed H. Elshafeey, Ahmed Abdelbary   +2 more
doaj   +1 more source