Results 141 to 150 of about 790,668 (339)

Confidence in preclinical research [PDF]

Lab Animal, 2017
openaire   +2 more sources

Executive summary: Workshop on preterm birth, January 28–29, 2025, co‐sponsored by the American College of Obstetricians and Gynecologists and the Eunice Kennedy Shriver National Institute of Child Health and Human Development

Pregnancy
The Society for Maternal‐Fetal Medicine collaborated with the American College of Obstetricians and Gynecologists and the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the National Institutes of Health to co‐sponsor ...
Society for Maternal‐Fetal Medicine (SMFM), Rupsa Boelig, Andrea Edlow, Tracy Manuck, Eva Pajkrt, Ina A. Stelzer, Sarahn Wheeler, Cynthia Gyamfi‐Bannerman   +7 more
doaj   +1 more source

Secondary Ischemia Assessment in Murine and Rat Preclinical Subarachnoid Hemorrhage Models: A Systematic Review

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Delayed cerebral ischemia represents a significant contributor to death and disability following aneurysmal subarachnoid hemorrhage. Although preclinical models have shown promising results, clinical trials have consistently failed to ...
Elias Fürstenau, Ute Lindauer, Henner Koch, Anke Höllig   +3 more
doaj   +1 more source

Practical solutions for including sex as a biological variable (SABV) in preclinical neuropsychopharmacological research

, 2023
Christina Dalla, Ivana Jarić, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Würbel, Jordan Marrocco, Jessica Tollkühn, Rebecca M. Shansky, Debra A. Bangasser, Jill B. Becker, Margaret M. McCarthy, Chantelle Ferland‐Beckham   +16 more
openalex   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

0321: Applications and Contrast Imaging with Micro-Ultrasound in Preclinical Cancer and Cardiovascular Research [PDF]

, 2009
F. Stuart Foster
openalex   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Patient and public involvement in preclinical and medical research: Evaluation of an established programme in a Discovery‐Based Medical Research Institute

Health Expectations
Background and Context Involving people with lived experience of health conditions and the public (consumers) in health research is supported by policy, practice and research funding schemes.
Robyn A. Smith, Judith Slocombe, Jo Cockwill, Kathy Minas, George Kiossoglou, Katya Gray, William Lawrence, Michelle Iddles, Clare Scott, Lorraine A. O'Reilly   +9 more
doaj   +1 more source

Technically Assisted Analysis of Large Quantities of Numerical Data in Preclinical Tumor Research [PDF]

, 2012
D. Pollig, Catherine Dißelhorst-Klug
openalex   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source