Results 131 to 140 of about 66,456,090 (253)

Approaches to modeling cancer metastasis: from bench to bedside

Frontiers in Oncology
Cancer metastasis modeling requires multidisciplinary approaches that integrate experimental, computational, and clinical research to unravel the complexities of cancer spread).
Leiyu Sun, Yajuan Zhou, Maoxu Yin, Fei Wang, Lijuan Yang   +4 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

In ovo model with emu eggs as novel alternative to animal testing in preclinical imaging research [PDF]

Background Large-size in ovo models are receiving increasing attention since they comply with the 3R requirements (Replacement, Reduction and Refinement) by limiting the number of fully developed laboratory animals.
Perkas, Olga, Porwoll, Veronika, Pomraenke, Marta, Freesmeyer, Martin, Herrmann, Karl-Heinz, Wiegand, Steffen, Kühnel, Christian, Winkens, Thomas   +7 more
core   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

PRECLINICAL IMAGING FACILITY-IBB website

, 2018
Preclinical imaging has become a powerful tool in biomedical research, allowing the non-invasive detection of biomarkers of disease. It enables the collection of anatomical, functional and dynamic imaging data from living experimental animals, including ...
Sara Gargiulo
core  

Of mice, molecules and mental health: establishment of the consortium for preclinical psychiatric research to find solutions to the translational gap

The Consortium for Preclinical Psychiatric Research (CPPR) recognises the current and ongoing major unmet translational needs in mental disorders and that to address this requires a collaborative multi-disciplinary approach uniting preclinical and ...
Hannan, A.J., Cui, X., Jaehne, E.J., Hill, R.A., Brown, R.M., Jawahar, M.C., Chesworth, R., Clemens, K.J., Foldi, C.J., Gatt, J.M., Berk, M., Gurvich, C., Harms, L., Hill-Yardin, E.L., Eratne, D., Dunn, A.L., Bastawy, E.M., et al., Burne, T.H., Clark, S.R., Gubert, C.   +20 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Executive summary: Workshop on preterm birth, January 28–29, 2025, co‐sponsored by the American College of Obstetricians and Gynecologists and the Eunice Kennedy Shriver National Institute of Child Health and Human Development

Pregnancy
The Society for Maternal‐Fetal Medicine collaborated with the American College of Obstetricians and Gynecologists and the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the National Institutes of Health to co‐sponsor ...
Society for Maternal‐Fetal Medicine (SMFM), Rupsa Boelig, Andrea Edlow, Tracy Manuck, Eva Pajkrt, Ina A. Stelzer, Sarahn Wheeler, Cynthia Gyamfi‐Bannerman   +7 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source