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Preclinical industrial research
Trends in Pharmacological Sciences, 1996From very early on in my career as a pharmacologist, I knew in my heart that I would do research in the pharmaceutical industy. This was not based on economical grounds, but was based on the fact that I am committed to participate in the discovery and development of drugs that will allievate human suffering.
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The zebrafish for preclinical psilocybin research
Neuroscience & Biobehavioral Reviews, 2023In this review, we discuss the possible utility of zebrafish in research on psilocybin, a psychedelic drug whose recreational use as well as possible clinical application are gaining increasing interest. First, we review behavioral tests with zebrafish, focussing on anxiety and social behavior, which have particular relevance in the context of ...
Omer A, Syed +2 more
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Preclinical research into cognition enhancers
Trends in Pharmacological Sciences, 2006The preclinical development of drugs to treat the cognitive symptoms of neuropsychiatric and neurological disorders is a formidable challenge. Evidence from a wide range of preclinical behavioral and neuropharmacological tests has formed the basis for predicting drug-induced cognition enhancement in normal volunteers and in patients with cognitive ...
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High field MRI in preclinical research
European Journal of Radiology, 2003High fields magnetic resonance imaging (MRI) experiments on humans have been historically limited by the so called "penetration effect" of B1 and by the power deposition in living tissues. The first effect refers to the non-homogeneous value of B1 field inside the sample (important when the wavelength of the r.f.
MARZOLA, Pasquina +2 more
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Preclinical models for translational sarcoma research
Current Opinion in Oncology, 2017Purpose of review Sarcoma is a basket term for mesenchymal tumors for which more than 75 genetically and histologically distinct subtypes are recognized. Therapeutic progress has largely been achieved with classical chemotherapeutic drugs that were tested in empirical clinical trials.
Hamacher, Rainer, Bauer, Sebastian
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Experimental models for preclinical cancer research
Experimental Cell Research, 2023The devastating disease of human cancers is a global health concern. In the past, development of effective therapies has been hindered by a shortage of reliable models; but in recent years, experimental models of human cancer for research are becoming more sophisticated.
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Hamster in preclinical research
Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)Members of the family Cricetidae in the order Rodentia are characterized by large cheek pouches that are used to transport and store food. In biomedical research the hamster is the third most frequently used laboratory animal following the rat and mouse.
M.N. Makarova, V.G. Makarov
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Preclinical Animal Models in Trauma Research
Journal of Orthopaedic Trauma, 2011Preclinical modeling of human disease with animals has not been standardized for many common pathologic processes. Assorted animal models are being used to investigate the pathogenesis, prevention, and treatment of disease processes. Certainly it is difficult to interpret the current literature because there are diverse and often irrelevant models ...
Edward J, Harvey +6 more
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False positive results in preclinical research
Therapies, 2017Therapie - Sous presse. Epreuves corrigees par l'auteur.
Denis, Angoulvant +1 more
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