Results 251 to 260 of about 790,668 (339)

Why non-human primates are needed in stroke preclinical research. [PDF]

Stroke Vasc Neurol
Long X, Zeng J.
europepmc   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Nuclear Imaging Strategies to Evaluate Cytokine Production in Autoimmune, Inflammatory, and Neoplastic Diseases: A Review of Current Preclinical Research. [PDF]

J Nucl Med
Deck A, Lane S, Liles A, Viola NT.
europepmc   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Preclinical research in obesity-associated metabolic diseases using in vitro, multicellular, and non-mammalian models. [PDF]

J Physiol Biochem
Aranaz P, Clavel-Millan M, Gil-Cardoso K, González-Arceo M, Hernández-González D, Les F, Salles J, Amri EZ, Arbones-Mainar JM, Atgié C, Capel F, Courtois A, Escoté X, García-Barrado MJ, Krisa S, López V, Milagro FI, Portillo MP, Lorente-Cebrián S.   +18 more
europepmc   +1 more source

Enhanced Endoscopic Internal Drainage of Gastric Abscess Through Additively Manufactured Stents

Advanced Healthcare Materials, EarlyView.
Postoperative gastric leaks are often treated with off‐label biliary double‐pigtail stents, yet conventional extruded designs are not optimized for leak anatomy, can migrate, and may limit abscess evacuation. PETALS is introduced to optimize transmural drainage geometry and enable patient‐specific 3D‐printable stents.
Parima Phowarasoontorn, Yongbin Ko, Juan S. Barajas‐Gamboa, Juan P. Pantoja, Oraib Al‐Ketan, Mohamed Ali, Sungyun Sohn, Heba Tageldeen Naser, Abdel‐Hameed Dabbour, Batoul Khlaifat, Ahmed AlZubaidi, Carlos Abril Vega, John Rodriguez, Matthew Kroh, Khalil B. Ramadi   +14 more
wiley   +1 more source

Patient-Derived Explants of Osteoarthritic Synovium as Ex Vivo Model for Preclinical Research. [PDF]

Int J Mol Sci
D'Oria C, Cincinelli G, Bason R, Pisati F, Simoncello F, Scotti I, Giudice L, Suardi I, Ferrua P, Fossati C, Randelli PS, Caporali R, Pagani M, Ingegnoli F.   +13 more
europepmc   +1 more source

Biomarkers of cardiovascular stress and fibrosis in preclinical hypertrophic cardiomyopathy [PDF]

, 2017
Canter, Charles, et al,
core   +1 more source

Technologies for Home Cage Monitoring in Preclinical Research [PDF]

Damien Huzard, Christopher K. Adams, Julio Álvarez, Michael Florea, Stefano Gaburro, Thomas Lorimer, Paul Mieske, Matt Ruiter, Oliver Sturman, Noah Weber, Davor Virag   +10 more
openalex   +1 more source

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

Advanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec, Randy Lee, Jingming Cao, Sophie Marolleau, Julien Nicolas, Sébastien Benzekry   +5 more
wiley   +1 more source