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[Preclinical research--toxicology].
Arzneimittel-Forschung, 1975The different steps of the toxicological testing of new drugs are shortly described. Furthermore it is discussed that only 60-70% of the drug induced adverse reactions in man can be predicted by the experimental methods being available at present.
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The Preclinical Research Process
1996The preclinical research process extends from early assessments of feasibility of pharmaceutical development to providing regulatory authorities and clinical trial units with information necessary for administering the product to human subjects. Chief concerns include safety, which is evaluated in well-defined preclinical toxicology programs, and ...
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Gerbils in preclinical research
Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)The Mongolian gerbil — Meriones unguiculatus — has been used in biomedical research recently compared to other rodents (mice, rats, guinea pigs). The gerbil is generally non-aggressive and is one of the easiest rodents to keep and handle. Relative resistance to natural infectious and adaptability to the environment have contributed to the expansion of ...
M.N. Makarova, V.G. Makarov
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[Preclinical research on Pharmachim's ronidazole].
Veterinarno-meditsinski nauki, 1986Ronidazol-Pharmachim (RPh) in the form of 10 per cent water-soluble powder was studied in terms of resistance to various values of pH of the surrounding medium, acute toxicity, the species-specific tolerance of various mammals of it, its subchronic toxicity and residual amounts with pigs.
P, Dilov +4 more
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[Acamprosate--new preclinical research aspects].
MMW Fortschritte der Medizin, 2004Acamprosate has been shown to be effective and safe in relapse prevention of alcoholism. The effect of acamprosate is explained by a functional antagonistic action on the N-methyl-D-aspartate (NMDA) receptor. Under normal physiological conditions acamprosate augments the functionality of the NDMA receptor, but it inhibits the overactivity of that ...
R, Spanagel, K, Mann
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Preclinical and clinical paediatric anaesthesia research
The Lancet Child & Adolescent Health, 2023Daniil P, Aksenov +3 more
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