Results 51 to 60 of about 7,653 (286)
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Derecho Penal y Criminología, 2011 Para abordar los problemas de la acusación se acude a otras figuras que incluye el derecho procesal colombiano. Afirmamos que no existe una regulación específica que se relacione con el retiro de la acusación y, por tanto, debemos acudir a los mecanismos
Ángela María Buitrago Ruiz
doaj +2 more sources
Redefining claim preclusion from verdict sovereignty: partial res judicata in jury trials
Revista Brasileira de Direito Processual Penal, 2020 Jury trials have presented themselves in history as an important instrument for the consolidation of democratic processes, because they are a tribunal for which the people are summoned to discuss and directly judge facts that have occurred in their ...
Paulo Gustavo Rodrigues
doaj +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Desigualdad de armas en lo militar dentro de nuestro ordenamiento procesal penal vigente [PDF]
, 2013 Por lo tanto, la materialización del principio de igualdad de armas en la etapa previa y la fase investigadora del proceso solo se concreta cada vez que las entidades públicas y privadas y de los particulares, prestan la colaboración que requiera la ...
Bohórquez Duque, Julio Cesar +1 more
core
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
FEBS Open Bio, EarlyView.Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
Principio de oportunidad y exclusión de la responsabilidad penal del adolescente desmovilizado del conflicto armado colombiano [PDF]
, 2012 Este trabajo está enfocado, principalmente, a analizar los aspectos de la política criminal que regula el proceso penal de los adolescentes desmovilizados del conflicto armado, el cual se orienta con fundamento en el Principio de Oportunidad consagrado ...
Montalvo Velásquez, Cristina
core
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source