Results 71 to 80 of about 1,894 (229)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
智慧財產案例有效性判斷爭議 ― 以美國法「爭點排除」為主 Disputed Issues in Deciding the Validity of Intellectual Property Right ― A Focus on Issue Preclusion [PDF]
Kējì Fǎxué Pínglùn, 2009 我國智慧財產訴訟新制結合民事、刑事、行政訴訟三種訴訟程序，法院就當事人主張或抗辯智慧財產權有應撤銷、廢止之原因者，對其主張或抗辯有無理由自為判斷之結果，引起民事、刑事、行政訴訟關於智慧財產有效性判斷歧異之問題。 智慧財產權有效性判斷歧異爭議或可藉由擴大爭點效之效力，以避免裁判歧異，美國法爭點排除（issue preclusion）相關理論值得加以參考。依智慧財產案件審理法第33條規定，並未明文限制當事人於前案訴訟程序中，就同一撤銷或廢止理由得提出而未提出智慧財權撤銷、廢止之新證據，不得另案主張 ...
陳國成 Kuo-Cheng Chen
doaj
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source
La cosa juzgada en torno a la preclusión y sus límites
, 1999 Analiza la preclusión, aplicaciones, además del orden preclusivo, una relación entre preclusión y carga procesal y la diferencia entre cosa juzgada y preclusión, además se hace un compendio de la cosa juzgada, conceptos, fundamento y su naturaleza, una ...
Torres Salamea, Pablo Fernando
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FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
La négation phrastique et les indéfinis négatifs en créole vincentien
Études Créoles, 2018 In this study we examine the co-occurrence or preclusion of negative words (n-words) with sentential negation in Vincentian Creole which has drawn much of its lexicon from English.
Paula Prescod
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen +7 more
wiley +1 more source
La preclusión (ta'ŷīz) en el derecho procesal mālikí: Un texto del Mufīd de Ibn Hišām.
, 2021 : Ibn Hishām al-Azdī (d. 1209), from Cordova, proposes in a passage of his Mufīd li-l-ḥukkām some of the circumstances which may come up in the application of the jurical institution of ta'jīz.Ibn Hišām al-Azdī (ob.
CARMONA GONZÁLEZ, Alfonso
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