Results 51 to 60 of about 1,894 (229)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Derecho Penal y Criminología, 2011 Para abordar los problemas de la acusación se acude a otras figuras que incluye el derecho procesal colombiano. Afirmamos que no existe una regulación específica que se relacione con el retiro de la acusación y, por tanto, debemos acudir a los mecanismos
Ángela María Buitrago Ruiz
doaj +2 more sources
Redefining claim preclusion from verdict sovereignty: partial res judicata in jury trials
Revista Brasileira de Direito Processual Penal, 2020 Jury trials have presented themselves in history as an important instrument for the consolidation of democratic processes, because they are a tribunal for which the people are summoned to discuss and directly judge facts that have occurred in their ...
Paulo Gustavo Rodrigues
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
El derecho fundamental a la prueba y la preclusión procesal en el marco del proceso civil peruano [PDF]
, 2020 La presente Tesis se titula ‘‘El Derecho Fundamental a la Prueba y la Preclusión Procesal en el marco del Proceso Civil Peruano’’, siendo que a través de ella se desarrolla el rol esencial que despliega el Derecho Fundamental a la Prueba en el ...
Cáceres Sifuentes, Cristian Carlos
core
Demanda: preclusión de hechos y alegaciones en procedimiento nuevo y su relación con la cosa juzgada [PDF]
, 2013 In this case, we analyze the extent and effects of claim preclusion of the facts and legal arguments in a lawsuit, established in the article 400 of Law 1/2000 on Civil Procedure and its relation to res judicata.En el presente caso se analiza la ...
Cabrejas Guijarro, María del Mar
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
La preclusión de la alegación de hechos y fundamentos jurídicos: el art. 400 de la LEC [PDF]
, 2020 El presente trabajo aborda el régimen jurídico de la preclusión de la alegación de hechos y fundamentos jurídicos del art. 400 de la Ley 1/2000 de Enjuiciamiento Civil, con especial incidencia en el ámbito subjetivo y objetivo del precepto, en su ...
Merino Cano, Javier +1 more
core
HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells
Stem Cells International, 2021 Although human induced pluripotent stem cells (iPSCs) can serve as a universal cell source for regenerative medicine, the use of iPSCs in clinical applications is limited by prohibitive costs and prolonged generation time.
Yoo-Wook Kwon +10 more
doaj +1 more source