Results 61 to 70 of about 22,452 (283)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Preclusion of radiation-mediated hematological and biochemical variations by root extract of Tinospora cordifolia (an indian medicinal plant) [PDF]

open access: yesNuclear Technology and Radiation Protection, 2013
The present study deals with the radiomodulatory influence of Tinospora cordifolia (Amrita) root extract on the peripheral blood of Swiss albino mice after 5.0 Gy gamma irradiation in the presence (experimental) or absence (control) of Tinospora
Sharma Priyanka, Goyal Pradeep K.
doaj   +1 more source

Matching preclusion number of graphs [PDF]

open access: yesTheoretical Computer Science, 2019
23 ...
Zhao Wang   +3 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

A "problem of time" in the multiplicative scheme for the $n$-site hopper

open access: yes, 2017
Quantum Measure Theory (QMT) is an approach to quantum mechanics, based on the path integral, in which quantum theory is conceived of as a generalised stochastic process. One of the postulates of QMT is that events with zero quantum measure do not occur,
Dowker, Fay   +3 more
core   +1 more source

Matching preclusion and strong matching preclusion of the bubble-sort star graphs

open access: yes, 2020
Since a plurality of processors in a distributed computer system working in parallel, to ensure the fault tolerance and stability of the network is an important issue in distributed systems. As the topology of the distributed network can be modeled as a graph, the (strong) matching preclusion in graph theory can be used as a robustness measure for ...
Wang, Xin, Ma, Chaoqun, Guo, Jia
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Location-selective immobilisation of single-atom catalysts on the surface or within the interior of ionic nanocrystals using coordination chemistry

open access: yesNature Communications, 2023
Single-atom catalysts dispersed on support materials show excellent heterogeneous catalytic properties that can be tuned using the interactions between the single atoms and the support.
Kenichi Endo   +2 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Litigation-Ending Sanctions: Alaska Courts’ Use of Rule 37 [PDF]

open access: yes, 1985
Pain is a common symptom of a number of conditions including cancer and one of the most frequent reasons for seeking healthcare. Acute and chronic pain result in considerable discomfort with a detrimental impact on the quality of life.
Carroll, Robert
core   +2 more sources

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