Central Precocious Puberty: Update on Diagnosis and Treatment [PDF]
Central precocious puberty (CPP) is characterized by the same biochemical and physical features as normally timed puberty but occurs at an abnormally early age. Most cases of CPP are seen in girls, in whom it is usually idiopathic.
Chen, Melinda, Eugster, Erica A.
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Management of post‐implant fibrous dysplasia in the maxilla: A case study
Abstract Background Fibrous dysplasia is generally rare, and even rarer in older adults. Special care is needed when altering the alveolar bone in these cases, especially if an implant is involved. This case study highlights such a scenario. Methods This case study details the experience of a 63‐year‐old African American female who presented with a ...
Yousef Taha Y. Amrou +4 more
wiley +1 more source
Parallel Increase in Childhood Anorexia Nervosa and Early Puberty During the COVID‐19 Pandemic
ABSTRACT Objective During the COVID‐19 pandemic, an increase in anorexia nervosa (AN), specifically childhood AN, as well as in central precocious puberty (CPP) and early‐onset puberty (EOP), was reported. The aim of this study was to explore whether there was a population‐level association between increases in both disorders and to discuss possible ...
Beate Herpertz‐Dahlmann +4 more
wiley +1 more source
Evo-devo of human adolescence: beyond disease models of early puberty [PDF]
Despite substantial heritability in pubertal development, much variation remains to be explained, leaving room for the influence of environmental factors to adjust its phenotypic trajectory in the service of fitness goals.
A Templeton +69 more
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Pollutant‐induced epithelial damage also leads to a cascade of harmful effects, including reduced mucus secretion, decreased luminal pH, and enhanced absorption of toxins. These changes contribute to oxidative stress (↑ malondialdehyde (MDA); ↓ superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), and heightened ...
Meysam Zarezadeh Ph.D. +5 more
wiley +1 more source
Bird's-eye view of GnRH analog use in a pediatric endocrinology referral center [PDF]
OBJECTIVE: Gonadotropin-releasing hormone analogs (GnRHa) are standard of care for the treatment of central precocious puberty (CPP). GnRHa have also been prescribed in other clinical settings with the hope of increasing adult stature, although ...
Eugster, Erica A. +3 more
core +1 more source
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret +5 more
wiley +1 more source
The Association of Gut Microbiota With Idiopathic Central Precocious Puberty in Girls
Idiopathic central precocious puberty (ICPP) is a relatively common condition in preadolescent girls, and its pathogenesis remains to be uncovered. A variety of studies have highlighted the association of gut microbiota (GM) with endocrine diseases, such
G. Dong +15 more
semanticscholar +1 more source
Association of Prenatal Urinary Concentrations of Phthalates and Bisphenol A and Pubertal Timing in Boys and Girls. [PDF]
BackgroundAnimal studies suggest that phthalates and bisphenol A (BPA), endocrine-disrupting chemicals found in many consumer products, may impact the timing of puberty.ObjectivesWe aimed to determine the association of prenatal exposure to high ...
Berger, Kimberly +9 more
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A reduction in long-term spatial memory persists after discontinuation of peripubertal GnRH agonist treatment in sheep [PDF]
Chronic gonadotropin-releasing hormone agonist (GnRHa) administration is used where suppression of hypothalamic-pituitary-gonadal axis activity is beneficial, such as steroid-dependent cancers, early onset gender dysphoria, central precocious puberty and
Bellingham, M. +6 more
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