Results 111 to 120 of about 1,275 (248)

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, EarlyView.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Computing Skinning Weights via Convex Duality

Computer Graphics Forum, EarlyView.
We present an alternate optimization method to compute bounded biharmonic skinning weights. Our method relies on a dual formulation, which can be optimized with a nonnegative linear least squares setup. Abstract We study the problem of optimising for skinning weights through the lens of convex duality.
J. Solomon, O. Stein
wiley   +1 more source

Hierarchical Differentiable Fluid Simulation

Computer Graphics Forum, EarlyView.
We introduce a two‐step algorithm that significantly reduces memory usage for solving control problems using differentiable fluid simulation techniques: our method first optimizes for bulk forces at reduced resolution, then refines local details over sub‐domains while maintaining differentiability. In trading runtime for memory, it enables optimization
Xiangyu Kong, Arnaud Schoentgen, Damien Rioux‐Lavoie, Paul G. Kry, Derek Nowrouzezahrai   +4 more
wiley   +1 more source

Progressively Projected Newton's Method

Computer Graphics Forum, EarlyView.
Abstract Newton's Method is widely used to find the solution of complex non‐linear simulation problems. To guarantee a descent direction, it is common practice to clamp the negative eigenvalues of each element Hessian prior to assembly—a strategy known as Projected Newton (PN)—but this perturbation often hinders convergence.
J. A. Fernández‐Fernández, F. Löschner, J. Bender   +2 more
wiley   +1 more source

Biodiversity‐driven spatial conservation planning to delineate temporally stable regions

Conservation Biology, EarlyView.
Abstract The accelerating loss of biodiversity underscores the critical need for effective conservation strategies, particularly in the face of climate change and anthropogenic pressures. We devised a conservation planning framework that adopts a temporal stacking approach to species distribution models and landscape connectivity analyses. These models
Mattia Iannella, Viviana Cittadino, Ilaria Bernabò, Antonio Romano, Maurizio Biondi, Davide Serva   +5 more
wiley   +1 more source

Effects of parent–child interaction therapy dosage on child and parent outcomes: differentiating child‐directed interaction and parent‐directed interaction session impacts in child welfare‐involved families

Journal of Child Psychology and Psychiatry, EarlyView.
Background Parent–child interaction therapy (PCIT) improves parenting and child behavior, yet little is known about how dosage of its two phases, warm relationship building focused child‐directed interaction (CDI) sessions and safe, effective discipline skills‐focused parent‐directed interaction (PDI) sessions, contributes to outcomes, particularly in ...
Xiaolan Liao, Julia P. Ruggiero, David E. Bard, Adon F. G. Rosen, Elizabeth A. Skowron   +4 more
wiley   +1 more source

A Comparative Analysis of Maillard‐Derived α‐Dicarbonyl Compounds and Advanced Glycation End Products in Fresh, Wet, Kibble, and Freeze‐Dried Dog Foods

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Thermal processing of pet foods can lead to the formation of harmful Maillard reaction products (MRPs), which may compromise nutritional quality and pose health risks to companion animals. This study compared the levels of MRPs in 41 commercial dog foods, including fresh (n = 15), kibble (n = 13), wet (n = 10), freeze‐dried (n = 2), and cold ...
Tolgahan Kocadağlı, Ciara Clarke, Vural Gökmen   +2 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source