Results 71 to 80 of about 1,731 (272)

Mannose‐Modified Cationic Liposome‐Based mRNA Therapeutics for Improved Triple‐Negative Breast Cancer Immunotherapy

open access: yesAdvanced NanoBiomed Research, EarlyView.
Schematic illustration of mTEM8‐loaded cationic liposome (cLipo‐Man/mTEM8) therapeutics for improved triple‐negative breast cancer immunotherapy. Despite triple‐negative breast cancer (TNBC) is the most heterogeneous and aggressive subtype of breast cancer, immunotherapy is emerging as a promising therapy.
Kexin Deng   +10 more
wiley   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg   +7 more
wiley   +1 more source

Interfacial Ru–O–W Orbital Coupling Enables Lattice Oxygen Stabilization for Enhanced Acidic OER

open access: yesCarbon Energy, EarlyView.
A RuO2/WO3 electrocatalyst with strong interfacial Ru–O–W bonds exhibits optimized Ru–O interactions, enhancing intrinsic activity and stability for acidic OER. The WO3 support modulates the electronic structure of RuO2 and promotes oxo‐intermediate deprotonation, delivering a low overpotential of 203 mV at 10 mA cm−2 and sustained operation beyond 200 
Tongzhou Wang   +9 more
wiley   +1 more source

Superionic Conduction Through Lattice Engineering of Fluorites Stabilizing Periodic Oxygen Vacancy Network

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Lattice‐engineered fluorite oxide with periodic oxygen vacancy network achieves superionic conduction, Ce4+–Al3+ fluorite cation ordering enables dielectric‐enhanced superionic conduction, surpassing the limitations of conventional doped electrolytes and high fuel cell performance at low temperature through a flattened energy landscape.
Shahzad Rasool   +18 more
wiley   +1 more source

Simulation of Fluid-Thermal Field in Oil-Immersed Transformer Winding Based on Dimensionless Least-Squares and Upwind Finite Element Method

open access: yesEnergies, 2018
In order to study the coupling fluid and thermal problems of the local winding in oil-immersed power transformers, the least-squares finite element method (LSFEM) and upwind finite element method (UFEM) are adopted, respectively, to calculate the fluid ...
Gang Liu   +4 more
doaj   +1 more source

Application of High‐Order Direct Flux Reconstruction and Stiffness‐Resilient Time Integration to Simulations of Idealized Atmospheric Flows

open access: yesInternational Journal for Numerical Methods in Fluids, EarlyView.
The proposed work implements a direct flux reconstruction method for spatial discretization and a stiffness‐resilient exponential time integration method for temporal discretization on the cube‐sphere grid. A space‐time tensor formalism is employed to provide a general representation in any curvilinear coordinate system. This combination enables highly
Stéphane Gaudreault   +6 more
wiley   +1 more source

Application of SSOR-PCGM with improved iteration format in FEM simulation of massive concrete

open access: yesWater Science and Engineering, 2011
In this study, for the purpose of improving the efficiency and accuracy of numerical simulation of massive concrete, the symmetric successive over relaxation-preconditioned conjugate gradient method (SSOR-PCGM) with an improved iteration format was ...
Lin Han, Zi-ming Zhang, Zhi-giang Ni
doaj   +1 more source

EVSS‐Based Simulation Techniques for the Viscoelastic Fluids With Pure Polymer Melts Using Three‐Field Approach

open access: yesInternational Journal for Numerical Methods in Fluids, EarlyView.
This paper presents a finite element method for simulating highly viscoelastic flows of pure polymer melts using the Elastic Viscous Stress Splitting formulation. The method avoids higher‐order derivatives in the weak formulation by reformulating the convective term in the constitutive equation.
R. Ahmad, P. Zajac, S. Turek
wiley   +1 more source

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