Results 71 to 80 of about 1,275 (248)

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Simulation of Fluid-Thermal Field in Oil-Immersed Transformer Winding Based on Dimensionless Least-Squares and Upwind Finite Element Method

Energies, 2018
In order to study the coupling fluid and thermal problems of the local winding in oil-immersed power transformers, the least-squares finite element method (LSFEM) and upwind finite element method (UFEM) are adopted, respectively, to calculate the fluid ...
Gang Liu, Zhi Zheng, Dongwei Yuan, Lin Li, Weige Wu   +4 more
doaj   +1 more source

Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa, Hayato Shimazaki, Shunji Igarashi, Yoshiki Tagawa, Naoki Hisada, Hiromi Shibasaki   +5 more
wiley   +1 more source

Application of SSOR-PCGM with improved iteration format in FEM simulation of massive concrete

Water Science and Engineering, 2011
In this study, for the purpose of improving the efficiency and accuracy of numerical simulation of massive concrete, the symmetric successive over relaxation-preconditioned conjugate gradient method (SSOR-PCGM) with an improved iteration format was ...
Lin Han, Zi-ming Zhang, Zhi-giang Ni
doaj   +1 more source

Prior-Preconditioned Conjugate Gradient Method for Accelerated Gibbs Sampling in "Large n, Large p" Bayesian Sparse Regression. [PDF]

J Am Stat Assoc, 2023
Nishimura A, Suchard MA.
europepmc   +1 more source

Interfacial Ru–O–W Orbital Coupling Enables Lattice Oxygen Stabilization for Enhanced Acidic OER

Carbon Energy, EarlyView.
A RuO2/WO3 electrocatalyst with strong interfacial Ru–O–W bonds exhibits optimized Ru–O interactions, enhancing intrinsic activity and stability for acidic OER. The WO3 support modulates the electronic structure of RuO2 and promotes oxo‐intermediate deprotonation, delivering a low overpotential of 203 mV at 10 mA cm−2 and sustained operation beyond 200 
Tongzhou Wang, Shoujian Duan, Junyu Pan, Jihong Li, Li Shao, Lei Shi, Yuhan Sun, Jingming Ran, Huaiyu Shao, Yida Deng   +9 more
wiley   +1 more source

Coupled Clustering in Hierarchical Matrices for the Oseen Problem

International Journal for Numerical Methods in Fluids, EarlyView.
Fluid flow problems can be modelled by the Navier‐Stokes or, after linearization, by the Oseen equations. Their discretization results in linear systems in saddle point form which are typically very large and need to be solved iteratively. We propose a novel block structure for hierarchical matrices which is then used to build preconditioners for the ...
Jonas Grams, Sabine Le Borne
wiley   +1 more source

Domain decomposition PCG methods for serial and parallel processing

Computer Assisted Methods in Engineering and Science, 2023
In this paper two domain decomposition formulations are presented in conjunction with the preconditioned conjugate gradient method (PCG) for the solution of large-scale problems in solid and structural mechanics.
M. Papadrakakis, S. Bitzarakis
doaj  

A preconditioned Conjugate Gradient Method on a distributed memory multiprocessor

Applied Mathematics Letters, 1995
Theoretical paper. Definition, theory and discussion of the implementation of a polynomial preconditioner for SPD matrix. No numerical example, no discussion of communication, no discussion for sparse matrix.
Bru, R., Corral, C., Mas, J.
openaire   +2 more sources

Local Polynomial Regression and Filtering for a Versatile Mesh‐Free PDE Solver

International Journal for Numerical Methods in Fluids, EarlyView.
A high‐order, mesh‐free finite difference method for solving differential equations is presented. Both derivative approximation and scheme stabilisation is carried out by parametric or non‐parametric local polynomial regression, making the resulting numerical method accurate, simple and versatile. Numerous numerical benchmark tests are investigated for
Alberto M. Gambaruto
wiley   +1 more source