Results 141 to 150 of about 54,023 (335)

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao   +5 more
wiley   +1 more source

Small vesicles, big potential: A review of innovative exosome delivery and molecular mechanisms in preclinical myocardial infarction models

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This narrative review discusses animal models of exosome‐based myocardial infarction treatments. Emerging techniques aim to improve exosome stability, targeting, and bioavailability for MI treatment as drug delivery vehicles and regenerative mediators that promote myocardial regeneration. Abstract Exosomes have emerged as promising therapeutic carriers,
Chayanisa Phutiyothin   +2 more
wiley   +1 more source

The Effects of Preconditioning with Normobaric Hyperoxia on Tissue Damage, Mechanical Performance and Arrhythmias Induced by Ischemia-Reperfusion in Isolated Heart of Morphine Dependent Rat

open access: yesResearch on Addiction, 2012
Introduction: Hyperoxia is an easy access preconditioner which attracts the researcher to use it in the clinic. Drug dependence is a widespread prevalence among different societies and one of the confounding factors in many diseases.
Raham Mazloom   +6 more
doaj  

A perspective from the Mesozoic: Evolutionary changes of the mammalian skull and their influence on feeding efficiency and high‐frequency hearing

open access: yesThe Anatomical Record, EarlyView.
Abstract The complex evolutionary history behind modern mammalian chewing performance and hearing function is a result of several changes in the entire skeletomuscular system of the skull and lower jaw. Lately, exciting multifunctional 3D analytical methods and kinematic simulations of feeding functions in both modern and fossil mammals and their ...
Julia A. Schultz
wiley   +1 more source

An inverse LU preconditioner based on the Sherman–Morrison formula

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica
An approximate inverse LU preconditioner is constructed based on the Sherman–Morrison formula. Applying recursively that inversion formula a multiplicative decomposition of the inverse of a matrix is obtained.
Bru R., Cerdán J., Marín J., Mas J.
doaj   +1 more source

Continuous Sewing Machine‐Like Suture Provides Higher Failure and Yield Load Compared to Traditional Techniques for Meniscal Root Repair in a Biomechanical Porcine Model

open access: yesArthroscopy, EarlyView.
Purpose To evaluate the biomechanical performance of the sewing machine‐like suture (SMS) technique against three established techniques (two cinch‐loop (TCL), modified Mason‐Allen (MMA), and double Mason‐Allen (DMA)) for transtibial pull‐out repair of posterior medial meniscal root tear (PMMRT) in a porcine model.
Yizhong Peng   +5 more
wiley   +1 more source

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